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SAB2500803

Sigma-Aldrich

Anti-Plasminogen Activator/PLAU antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-ATF, Anti-HGNC:9052, Anti-Plasminogen activator, Anti-UPA, Anti-Urokinase
MDL number:

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PLAU(5328)

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HPA008719WH0005340M1HPA050843
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

UniProt accession no.

P00749

UniProt accession no.

P00749

UniProt accession no.

P00747

UniProt accession no.

Q03405

technique(s)

indirect ELISA: suitable, western blot: suitable

technique(s)

immunohistochemistry: 1:200- 1:500

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

technique(s)

immunohistochemistry: 1:50-1:200

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

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General description

Urokinase-type plasminogen activator is also known as PLAU and uPA. The human uPA is initially synthesized as 431 amino acid precursor with an N-terminal signal peptide (20 residues). The single chain molecule is processed into a disulfide-linked two-chain molecule of different molecular weights. Two forms of the A chain exist, starting at Ser21 (the long form) and Lys156 (the short form). The long and short A chains are unique to the high and low molecular weight forms, respectively. The long A chain contains an EGF (epidermal growth factor)-like domain, responsible for binding of the PLAU receptor. The B chain corresponds to the catalytic domain. The gene encoding it is localized on human chromosome 10.

Immunogen

Peptide with sequence C-HFLPWIRSHTKEEN from the C Terminus of the protein sequence according to NP_002649.1.

Biochem/physiol Actions

Urokinase-type plasminogen activator is a serine protease with extremely limited substrate specificity, cleaving the sequence Cys-Pro-Gly-Arg560-Val561-Val-Gly-Gly-Cys in plasminogen to form plasmin. It is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Exclamation mark

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Yasuda S
Blood, 105(10), 3893-3901 (2005)
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Spraggon G
Structure, 3(7), 681-691 (1995)
Identification of a novel inhibitor of urokinase-type plasminogen activator.
Zhu M
Molecular Cancer Therapeutics, 6(4), 1348-1356 (2007)

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