SAB3500084

Anti-IRGC antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CINEMA, Anti-Immunity-related GTPase cinema 1, Anti-Interferon-inducible GTPase 5, Anti-Ligp5
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human, rat
• technique(s): immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_062558
• UniProt accession no.: Q6NXR0
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IRGC(56269)

Description

Immunogen

IRGC antibody was raised against a 12 amino acid peptide near the carboxy terminus of human IRGC.

Features and Benefits

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Target description

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500084.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable