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Anti-TRMT12 antibody produced in rabbit

affinity isolated antibody

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biological source


Quality Level



antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

49 kDa

species reactivity

human, mouse


1 mg/mL


ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

UniProt accession no.

shipped in

wet ice

storage temp.


target post-translational modification


Gene Information

human ... TRMT12(55039)

General description

TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.


Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.

Biochem/physiol Actions

TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.

Features and Benefits

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The action of this antibody can be blocked using blocking peptide SBP3500666.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Storage Class

10 - Combustible liquids


Not applicable


Not applicable

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