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Key Documents

SAB4301310

Sigma-Aldrich

Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

E2AK3, EIF2AK3, PEK, PERK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

125 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: 1:50-1:100

isotype

IgG

accession no.

NP_004827.4.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr981)

Gene Information

human ... EIF2AK3(9451)

Related Categories

General description

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/EIF2AK3 (eukaryotic translation initiation factor 2 α kinase 3) is a type I transmembrane protein, located on ER (endoplasmic reticulum). It is a member of the eIF2α kinase subfamily. This gene is located on human chromosome 2p. EIF2AK3 has 16 exons and is made of cytoplasmic and kinase domains.

Specificity

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

Immunogen

Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK.

Biochem/physiol Actions

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) helps to detect the protein-folding imbalance created by endoplasmic reticulum (ER) stress. EIF2AK3 works as an endoplasmic reticulum (ER) stress sensor to modulate global protein synthesis. Mutation in EIF2AK3 gene results in Wolcott-rallison syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.
Wang P, et al.
Acta crystallographica. Section D, Structural biology, 72(12), 1290-1297 (2016)
Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient.
Slingerland AS.
Reviews in Endocrine & Metabolic Disorders, 7(3), 171-185 (2006)
Wolcott-Rallison Syndrome with Novel EIF2AK3 Gene Mutation.
Gurbuz F, et al.
Journal of Clinical Research in Pediatric Endocrinology, 8(4), 496-496 (2016)
Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.
Liu Z, et al.
Cell Death & Disease, 6(7), e1822-e1822 (2015)
A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density.
Liu J, et al.
Journal of Bone and Mineral Research, 27(2), 331-341 (2012)

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