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SAB4301399

Sigma-Aldrich

Anti-phospho-DRP1 (pSer637) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
DLP1, DNM1L, DRP1, DVLP, Dymple
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

82 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_036192.2.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer637)

Gene Information

human ... DNM1L(10059)

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Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

mol wt

82 kDa

mol wt

60, 78, 79, 80, 81, 82, 83

mol wt

82 kDa

mol wt

antigen ~104.21 kDa

Gene Information

human ... DNM1L(10059)

Gene Information

human ... DNM1L(10059)

Gene Information

human ... DNM1L(10059)

Gene Information

human ... DNM1L(10059)

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

1D6, monoclonal

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General description

Dynamin related protein 1 (DRP1) is a dynamin-related guanosine triphosphatase. The gene is located on human chromosome 12p11.21. DRP1 is a cytosolic protein, which is also present on the outer mitochondrial membrane.

Specificity

The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Immunogen

Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1.

Application

Anti-phospho-DRP1 (pSer637) antibody produced in rabbit has been used in immunoblotting and western blotting.

Biochem/physiol Actions

Dynamin related protein 1 (DRP1) is an important regulator of mitochondrial fission and peroxisomal division. It regulates proper mitochondrial function, apoptosis and necrosis. Mutations in this gene is associated with Alzheimer′s disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells
Huang Y and Hu Z
Journal of Cellular Physiology, 233(9), 7480-7496 (2018)
Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages
Escoll P, et al.
Cell host & microbe, 22(3), 302-316 (2017)
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
Gomez-Lazaro, et al.
Free Radical Biology & Medicine, 44(11), 1960-1969 (2008)
Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers
Kim YY, et al.
Acta biochimica et biophysica Sinica, 50(2), 209-215 (2018)
S-nitrosylation of Drp1 mediates ?-amyloid-related mitochondrial fission and neuronal injury
Cho DH, et al.
Science, 324(5923), 102-105 (2009)

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