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SAB4504499

Sigma-Aldrich

Anti-phospho-p53 (pSer15) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-BCC7, Anti-BMFS5, Anti-LFS1, Anti-P53, Anti-TRP53
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 43 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer15)

Gene Information

human ... TP53(7157)

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This Item
SAB4503001SAB4503013SAB4503011
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000, immunohistochemistry: 1:50-1:100

technique(s)

ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

ELISA: 1:1000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

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General description

TP53 (tumor protein p53) gene is located on human chromosome 17p13.1. This is a tumor-suppressor gene.

Immunogen

The antiserum was produced against synthesized peptide derived from human p53 around the phosphorylation site of Ser15.

Immunogen Range: 1-50

Biochem/physiol Actions

TP53 (tumor protein p53) gene is required for the DNA-damage checkpoint.This protein controls cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Mutation in TP53 results in breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Assessing TP53 status in human tumours to evaluate clinical outcome.
Soussi T and Beroud C
Nature Reviews. Cancer, 1(3), 233-233 (2001)
Wip1 phosphatase: between p53 and MAPK kinases pathways.
Goloudina AR, et al.
Oncotarget, 7(21), 31563-31571 (2016)
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.
Fountzilas G, et al.
Oncotarget, 7(22), 32731-32753 (2016)

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