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SAB4700217

Sigma-Aldrich

Monoclonal Anti-CD63-FITC antibody produced in mouse

clone MEM-259, purified immunoglobulin, buffered aqueous solution

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biological source

mouse

Quality Level

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MEM-259, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD63(967)

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SAB4700215SAB4700216SAB4700210
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

clone

MEM-259, monoclonal

clone

MEM-259, monoclonal

clone

MEM-259, monoclonal

clone

MEM-43, monoclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

Gene Information

human ... CD63(967)

Gene Information

human ... CD63(967)

Gene Information

human ... CD63(967)

Gene Information

human ... CD59(966)

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General description

CD63 belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes, and is also present in the platelet dense granule membrane.

Immunogen

HPB-ALL T cell line

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Biochem/physiol Actions

CD63 is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Improved metabolic control deduce platelet activation marker in the type-2 diabetes patients and helps in reducing development of diabetic late complications. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions such as cellular adhesion, cell differentiation, migration, carcinogenesis, and tumor progression. CD63 is highly expressed in initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.
Nishibori M, et al.
The Journal of Clinical Investigation, 91(4), 1775-1782 (1993)
Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression.
Woegerbauer M, et al.
Modern Pathology, 23(5), 751-762 (2010)
A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.
Berditchevski F, et al.
The Journal of Biological Chemistry, 272(5), 2595-2598 (1997)
Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes.
Eibl N, et al.
European Journal of Clinical Investigation, 34(3), 205-209 (2004)

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