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SAB4700391

Sigma-Aldrich

Monoclonal Anti-CD11c-APC antibody produced in mouse

clone BU15, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-ITGAX
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

Allophycocyanin conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BU15, monoclonal

form

buffered aqueous solution

species reactivity

human, monkey, canine

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... ITGAX(3687)

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This Item
SAB4700393C0551SAB4700378
species reactivity

human, monkey, canine

species reactivity

monkey, canine, human

species reactivity

human

species reactivity

human

clone

BU15, monoclonal

clone

BU15, monoclonal

clone

ICRF44, monoclonal

clone

MEM-25, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

Allophycocyanin conjugate

conjugate

phycoerythrin (R-PE) conjugate

conjugate

unconjugated

conjugate

Allophycocyanin conjugate

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

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General description

Cluster of differentiation 11c (CD11c), also known as integrin subunit α X (ITGAX), is an antigen receptor, encoded by the gene mapped to human chromosome 16p11.2. The encode protein belongs to the adhesion molecule integrin family and is mainly expressed in natural killer cells, macrophages and even some activated B and T cells.
The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.

Immunogen

Dendritic cells of synovial fluid

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.

Biochem/physiol Actions

Cluster of differentiation 11c (CD11c) delivers co-stimulatory signals to activated lymphocytes. Elevated expression of the gene decreased the risk of death and relapse in gastric cancer (GC) patients. The protein can be considered as an alternative prognosis marker for GC. Overexpression of CD11c in CD8+ cells might lead to the development of Behcet′s disease (BD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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The integrins
Takada Y
Genome Biology, 8 (2007)
High expression of CD11c indicates favorable prognosis in patients with gastric cancer
Wang Y
World Journal of Gastroenterology, 21, 9403-9412 (2015)
CD11c is upregulated in CD8+ T cells of patients with Behcet's disease.
Park YJ
Clinical and Experimental Rheumatology, 34, S86-S91 (2016)

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