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SAB5700277

Sigma-Aldrich

Anti-Phospho-APP-T668 antibody produced in rabbit

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Synonym(s):
Aβ42, AAA, ABETA, ABPP, AD1, APP, APPI, Amyloid beta A4, CTFgamma, CVAP, PN-II, PN2, preA4

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

34
72-86

species reactivity

rat, mouse

concentration

0.81 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr668)

Gene Information

human ... APP(351)

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vibrant-m

MABN2297

Anti-APP Antibody, clone 7H6

biological source

rabbit

biological source

rat

biological source

rat

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

shipped in

wet ice

shipped in

ambient

shipped in

ambient

shipped in

wet ice

clone

polyclonal

clone

7H6, monoclonal

clone

2E9, monoclonal

clone

mC99(1-7), monoclonal

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

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General description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Immunogen

A phospho specific peptide corresponding to residues surrounding T668 of human APP

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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