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SAB5700317

Sigma-Aldrich

Anti-Phospho-MDM2-S166 antibody produced in rabbit

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Synonym(s):
ACTFS, HDMX, MDM2, hdm2

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

11-14
24-55

species reactivity

rat, mouse, human

concentration

0.63 mg/ml

technique(s)

immunofluorescence: 1:50-1:100
western blot: 1:500-1:1000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer166)

Gene Information

human ... MDM2(4193)

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This Item
SAB4501849SAB4300284SAB4300601
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

mol wt

11-14, 24-55

mol wt

antigen 55 kDa

mol wt

~90 kDa

mol wt

~90 kDa

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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General description

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Immunogen

A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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