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SAB5700620

Sigma-Aldrich

Anti-CDKN2A/p16INK4a antibody produced in rabbit

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Synonym(s):
ARF, CDK4I, CDKN2, CDKN2A, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

11
12
13
16
17
8

species reactivity

human, rat, mouse

concentration

1.21 mg/ml

technique(s)

immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDKN2A(1029)

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This Item
SAB5701004SAB5701126SAB4500072
antibody form

affinity isolated antibody

antibody form

-

antibody form

-

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

Gene Information

human ... CDKN2A(1029)

Gene Information

human ... CDKN2A(1029)

Gene Information

human ... CDKN2A(1029)

Gene Information

human ... CDKN2A(1029)

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

mol wt

11, 13, 17, 12, 8, 16

mol wt

-

mol wt

-

mol wt

antigen 16 kDa

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General description

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 20 to the C-terminus of human CDKN2A / p16INK4a

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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