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SAB5701785

Sigma-Aldrich

Anti-Phospho-ATR-S428 antibody produced in rabbit

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biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

form

liquid

species reactivity

human

concentration

0.4 mg/mL

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer428)

Gene Information

human ... ATR(545)

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This Item
SAB4300576SAB5701862SAB5701319
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

clone

polyclonal

clone

polyclonal

clone

monoclonal

clone

monoclonal

UniProt accession no.

Q13535

UniProt accession no.

Q13535

UniProt accession no.

Q13315

UniProt accession no.

Q13315

species reactivity

human

species reactivity

human

species reactivity

human, rat

species reactivity

mouse, rat, human

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Immunogen

A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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