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SML0393

Sigma-Aldrich

QNZ46

≥98% (HPLC)

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Synonym(s):
4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
Empirical Formula (Hill Notation):
C24H17N3O6
CAS Number:
Molecular Weight:
443.41
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (warmed; clear solution)

storage temp.

room temp

SMILES string

COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O

InChI

1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+

InChI key

GNLVJIICVWDSNI-LFYBBSHMSA-N

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SML0510PZ0348PZ0285
QNZ46 ≥98% (HPLC)

SML0393

QNZ46

S 26948 ≥98% (HPLC)

SML0510

S 26948

NI-42 ≥98% (HPLC)

PZ0348

NI-42

PD168393 ≥98% (HPLC)

PZ0285

PD168393

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 5 mg/mL (warmed; clear solution)

solubility

DMSO: 10 mg/mL (clear solution)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 25 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC50 values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Reshmi Tognatta et al.
Frontiers in cellular neuroscience, 14, 74-74 (2020-04-18)
Astrocytes have been implicated in regulating oligodendrocyte development and myelination in vitro, although their functions in vivo remain less well defined. Using a novel approach to locally ablate GFAP+ astrocytes, we demonstrate that astrocytes are required for normal CNS myelin

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