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SML0604

Sigma-Aldrich

SB-399885 hydrochloride

≥98% (HPLC)

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Synonym(s):
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride
Empirical Formula (Hill Notation):
C18H21Cl2N3O4S · HCl
CAS Number:
Molecular Weight:
482.81
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

room temp

InChI

1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3

InChI key

ATKZKAYWARYLBW-UHFFFAOYSA-N

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This Item
SML0608SML0276S7326
Sigma-Aldrich

SML0604

SB-399885 hydrochloride

Sigma-Aldrich

SML0608

A-412997 dihydrochloride

BD 1063 dihydrochloride ≥98% (HPLC)

SML0276

BD 1063 dihydrochloride

SB 657510 ≥98% (HPLC)

S7326

SB 657510

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

H2O: 15 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

H2O: >15 mg/mL

solubility

DMSO: ≥30 mg/mL

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

Biochem/physiol Actions

SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist with greater than 200 fold selectivity over other 5-HT receptors. SB-399885 is brain penetrant and displays antidepressant and anxiolytic activity in rodent models.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ao Li et al.
CNS neuroscience & therapeutics, 27(8), 941-950 (2021-05-12)
General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness

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