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SML0607

Sigma-Aldrich

Ceranib-2

≥98% (HPLC)

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Synonym(s):
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone, 3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone
Empirical Formula (Hill Notation):
C25H19NO3
CAS Number:
Molecular Weight:
381.42

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

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This Item
SML2689SML1085L2545
Sigma-Aldrich

SML0607

Ceranib-2

EN6 ≥98% (HPLC)

SML2689

EN6

Retro-2 ≥98% (HPLC)

SML1085

Retro-2

LY225910 ≥98% (HPLC)

L2545

LY225910

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: >20 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

off-white

Biochem/physiol Actions

Ceranib-2 is a nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and inhibits cell proliferation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Violeta Heras et al.
Cell metabolism, 32(6), 951-966 (2020-10-21)
Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ceramides participate in the control of female
Gang Pei et al.
The EMBO journal, 40(13), e106272-e106272 (2021-05-05)
Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated stress inducers were employed to screen for sensors linking altered cellular homeostasis and inflammation. We identified the intracellular pattern recognition receptors NOD1/2

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