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SML0768

Sigma-Aldrich

GSK2801

≥98% (HPLC)

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Synonym(s):
1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone
Empirical Formula (Hill Notation):
C20H21NO4S
Molecular Weight:
371.45
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

, white to pink to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

CCCOC1=CC2=C(C3=CC=CC=C3S(=O)(C)=O)C=C(C(C)=O)N2C=C1

InChI

1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3

InChI key

KHWCPNJRJCNVRI-UHFFFAOYSA-N

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GSK2801 ≥98% (HPLC)

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GSK2801

UNC0642 ≥98% (HPLC)

Sigma-Aldrich

SML1037

UNC0642

L-368,899 ≥98% (HPLC), powder

Sigma-Aldrich

L2540

L-368,899

UNC0638 hydrate ≥98% (HPLC)

Sigma-Aldrich

U4885

UNC0638 hydrate

form

powder

form

powder

form

powder

form

solid

storage condition

protect from light

storage condition

-

storage condition

-

storage condition

protect from light

color

, white to pink to light brown

color

white to beige

color

white

color

off-white

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

H2O: soluble 20 mg/mL

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

GSK2801 is a potent inhibitor of the BAZ2 family of bromodomain containing proteins. BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifying enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. For full characterization details, please visit the GSK2801 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

GSK2801 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

GSK2801 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK2801 probe summary on the Chemical Probes Portal website.
Light sensitive

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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