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SML2650

Sigma-Aldrich

T3-CLK

≥98% (HPLC)

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Synonym(s):
4-(2-Methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide, 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide, T3
Empirical Formula (Hill Notation):
C28H30N6O2
CAS Number:
Molecular Weight:
482.58
MDL number:

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

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This Item
SML2649SML0766SML2718
T3-CLK ≥98% (HPLC)

SML2650

T3-CLK

T3-CLK-N ≥98% (HPLC)

SML2649

T3-CLK-N

GSK343 ≥98% (HPLC)

SML0766

GSK343

GSK503 ≥98% (HPLC)

SML2718

GSK503

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

, white to beige to brown

color

white to beige

Biochem/physiol Actions

T3-CLK (T3) is a cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK) that exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3-CLK increases conjoined gene (CG) transcription.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Susanne Müller et al.
eLife, 7 (2018-04-21)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and
Tyler Funnell et al.
Nature communications, 8(1), 7-7 (2017-02-25)
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure

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