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SML2960

Sigma-Aldrich

Nizatidine

≥98% (HPLC)

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Synonym(s):
Nizatidine, LY 139037, N′-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine, N-{2-[2-(N,N-Dimethylaminomethyl)-4-thiazolylmethylthio]ethyl}-N′-methyl-2-nitro-1,1-ethenediamine
Empirical Formula (Hill Notation):
C12H21N5O2S2
CAS Number:
Molecular Weight:
331.46

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+

InChI key

SGXXNSQHWDMGGP-IZZDOVSWSA-N

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Biochem/physiol Actions

Nizatidine is a potent and selective antagonist of histamine H2 receptors used for treatment of stomach and intestine ulcers. Also, it was recommended as a component of combination therapy for cancer treatment. New data indicate that it can be repurposed to treat subtypes of clear cell renal cell carcinoma (ccRCC) in patients expressing certain isoforms of the pyruvate kinase muscle type. Additionally, nizatidine increases utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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