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About This Item
Empirical Formula (Hill Notation):
C105H188N42O30 · xC2HF3O2
CAS Number:
Molecular Weight:
2518.88 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Biochem/physiol Actions
NMDAR-PSD-95 interaction blocking peptide with neuroprotective efficacy in vitro and in vivo.
Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV that blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset).
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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