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SML3052

Sigma-Aldrich

ppTG21 trifluoroacetate salt

≥95% (HPLC)

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Synonym(s):
GLFHALLHLLHSLWHLLLHA-OH TFA salt, Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala TFA salt
Empirical Formula (Hill Notation):
C115H173N31O22 · xC2HF3O2
Molecular Weight:
2341.80 (free base basis)

Quality Level

assay

≥95% (HPLC)

form

film or powder

color

white to beige

storage temp.

−20°C

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ppTG21 trifluoroacetate salt

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Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

film or powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white to beige

color

-

color

-

color

white to off-white

Biochem/physiol Actions

ppTG21 is an endosomolytic agent (pI 7.7, charge +1.3 @ pH 7.4) that facilitates cell type-specific gene editing by enabling endosome escape of Cas9 ribonucleoprotein (RNP) complex following its uptake via receptor-mediated endocytosis. Following liver-specific asialoglycoprotein receptor (ASGPr)-mediated delivery of ASGPr ligand (ASGPrL)-harboring & SV40 nuclear localization sequence (NLS)-bearing S. pyogenes Cas9 (Cas9-2lig-1NLS) RNP with EMX1-targeting sgRNA, target gene editing occurs only upon coincubation of the RNP in the presence of 30 molar equiv of ppTG21 (ave 4.8% indels in HepG2 cells vs. 0.2% indels without ppTG21).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Romain Rouet et al.
Journal of the American Chemical Society, 140(21), 6596-6603 (2018-04-19)
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research and clinical uses of these enzymes. We report
Karola Rittner et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 5(2), 104-114 (2002-02-07)
We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine
Ning Hu et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 3239-3245 (2019-08-01)
Osteoarthritis (OA) is a major public health concern for which a reliable non-invasive treatment option has yet to be developed. In the present study, we investigated the effects of saxagliptin, a novel dipeptidyl peptidase IV (DPP-4) inhibitor, on several important

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