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SML3084

Sigma-Aldrich

Clascoterone

≥98% (HPLC)

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Synonym(s):
21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione, C17P, CB-03-01, Cortexolone 17α-propionate
Empirical Formula (Hill Notation):
C24H34O5
CAS Number:
Molecular Weight:
402.52
MDL number:

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCC(O[C@]1(C(CO)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

InChI

1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1

InChI key

GPNHMOZDMYNCPO-PDUMRIMRSA-N

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This Item
R0500SML2932SML1480
vibrant-m

SML3084

Clascoterone

vibrant-m

R0500

Reichstein′s substance S

vibrant-m

SML2932

Dexamethasone palmitate

vibrant-m

SML1480

Alclometasone dipropionate

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

-

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

ethanol: 50 mg/mL, clear, colorless to faint yellow or tan

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

Biochem/physiol Actions

Clascoterone is a high-affinity androgen receptor (AR) antagonist (antiandrogen) that antagonizes testosterone-stimulated transcription activity (in reporter cells) as well as DHT-induced production of lipids and inflammatory cytokines (in human sebocytes) in cultures. When applied topically, clascoterone is as active as cyproterone acetate, and 2-, 3-, and 4-times, respectively, more active than finasteride, flutamide, and progesterone in vivo (local antiandrogenic activity in hamster′s flank organ; 100-400 μg/50 μL acetone/animal).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Patrizia Ferraboschi et al.
Steroids, 128, 95-104 (2017-09-20)
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of
Caridad Rosette et al.
Journal of drugs in dermatology : JDD, 18(2), 197-201 (2019-02-28)
Cortexolone 17α-propionate (clascoterone) is a novel androgen antagonist that is currently being analyzed in a large phase 2 clinical trial for the topical treatment of androgenetic alopecia (AGA). While the pathogenesis of AGA is still debated, the consensus is that
Caridad Rosette et al.
Journal of drugs in dermatology : JDD, 18(5), 412-418 (2019-05-31)
Cortexolone 17α-propionate (clascoterone) is a novel topical androgen antagonist that is being analyzed for its ability to treat acne. The pathogenesis of acne is attributed to multiple factors, including altered sebum production, inflammatory processes, dysregulation of the hormone microenvironment, and
Cortexolone 17α-propionate for hidradenitis suppurativa.
Samuel Antranig Der Sarkissian et al.
Dermatologic therapy, 33(6), e14142-e14142 (2020-08-08)

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