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SML3464

Sigma-Aldrich

Gossypetin

≥98% (HPLC)

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Synonym(s):
2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one, 8-Hydroxyquercetin, Articulatidin, Equisporol
Empirical Formula (Hill Notation):
C15H10O8
CAS Number:
Molecular Weight:
318.24
MDL number:

Quality Level

assay

≥98% (HPLC)

form

powder

color

, light green to yellow

solubility

DMSO: 2 mg/mL, clear

Storage temp.

-10 to -25°C

SMILES string

OC1=CC(O)=C2C(C(O)=C(OC2=C1O)C3=CC=C(C(O)=C3)O)=O

InChI

1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H

Inchi Key

YRRAGUMVDQQZIY-UHFFFAOYSA-N

Biochem/physiol Actions

Gossypetin is a hexahydroxylated flavonoid found in the flowers and the calyx of Hibiscus, which exhibits numerous pharmacological effects, including antioxidant, antibacterial and anticancer activities. It induces apoptosis and autophagic cell death in prostate cancer cells. Gossypetin is a potent inhibitor of MKK3 and MKK6 protein kinases that suppresses esophageal cancer growth.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Morgana V Araújo et al.
The Analyst, 144(17), 5232-5244 (2019-07-31)
Leishmaniasis comprises a group of infectious diseases with worldwide distribution, of which both the visceral and cutaneous forms are caused by Leishmania parasites. In the absence of vaccines, efficacious chemotherapy remains the basis for leishmaniasis control. The available drugs are
Xiaomeng Xie et al.
Cancer letters, 442, 126-136 (2018-11-06)
Gossypetin as a hexahydroxylated flavonoid found in many flowers and Hibiscus. It exerts various pharmacological activities, including antioxidant, antibacterial and anticancer activities. However, the anticancer capacity of gossypetin has not been fully elucidated. In this study, gossypetin was found to
Ming-Shih Lee et al.
Molecular carcinogenesis, 56(12), 2578-2592 (2017-07-04)
Gossypetin (GTIN), a naturally occurring hexahydroxy flavone, has been shown to possess antimutagenic, antioxidant, antimicrobial, and antiatherosclerotic effects. Here, we investigated the mechanism(s) underlying the anticancer potential of GTIN. In this study, investigations were showed that GTIN preferentially induces programed

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