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SRP0363

Sigma-Aldrich

Cot active mouse

recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)

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Synonym(s):
Cot, Map3k8, Tpl2, mitogen-activated protein kinase kinase kinase 8
NACRES:
NA.32

biological source

mouse

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥50% (SDS-PAGE)

form

aqueous solution

mol wt

70 kDa

packaging

pkg of 10 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... MAP3K8(26410)

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vibrant-m

SRP0363

Cot active mouse

vibrant-m

SRP0247

MAP3K14(NIK) Active human

vibrant-m

SRP0365

p70S6K active human

assay

≥50% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

Gene Information

mouse ... MAP3K8(26410)

Gene Information

human ... MAP3K14(9020)

Gene Information

human ... RPS6KB1(6198)

Gene Information

human ... PIK3CD(5293)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected insect cells

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

Mouse Cot kinase (MAP3K8) (GenBank Accession No. NM_007746), amino acids 30-397 with N-terminal His-GST-tag, expressed in a Baculovirus infected Sf9 cell expression system.

Physical form

Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.4 mM KCl, 5 mM glutathione, 134 mM imidazole, 3 mM DTT and 20% glycerol.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Joseph H Jeong et al.
PloS one, 6(1), e16205-e16205 (2011-01-27)
Despite its initial positive response to hormone ablation therapy, prostate cancers invariably recur in more aggressive, treatment resistant forms. The lack of our understanding of underlying genetic alterations for the transition from androgen-dependent (AD) to ADI prostate cancer growth hampers
Irene Soria-Castro et al.
The Journal of biological chemistry, 285(44), 33805-33815 (2010-08-26)
Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar injection of zymosan, Cot/tpl2(-/-)

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