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SRP2094

Sigma-Aldrich

Fos-related antigen 1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

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Synonym(s):
FRA, FRA1, fra-1
NACRES:
NA.26

biological source

human

recombinant

expressed in insect cells

assay

≥70% (SDS-PAGE)

form

frozen liquid

mol wt

~31.2 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

350 μg/mL

color

colorless to clear

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FOSL1(8061)

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This Item
SRP2070SRP2046SRP2031
Fos-related antigen 1 human recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

SRP2094

Fos-related antigen 1 human

LRH-1 human recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

SRP2070

LRH-1 human

CTF1 human recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

SRP2031

CTF1 human

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

mol wt

~31.2 kDa

mol wt

~62.6 kDa

mol wt

~56.5 kDa

mol wt

~56.4 kDa

UniProt accession no.

P15407

UniProt accession no.

O00482

UniProt accession no.

P10827

UniProt accession no.

Q16619

Biochem/physiol Actions

The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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D R Cohen et al.
Genes & development, 3(2), 173-184 (1989-02-01)
fra-1 encodes a serum-inducible protein (Fra-1) that is antigenically related to Fos. We have characterized Fra-1 expression in serum-stimulated cells using antibodies raised against several regions of this protein. Fra-1, expressed transiently in COS cells or in serum-stimulated rat fibroblasts
M Matsui et al.
Oncogene, 5(3), 249-255 (1990-03-01)
cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues
Pavan Adiseshaiah et al.
The Journal of biological chemistry, 278(48), 47423-47433 (2003-09-19)
Recent studies indicate a potential role for Fra-1, a heterodimeric partner of activator protein 1 (AP1), in toxicant-induced epithelial injury, repair, and cellular transformation. Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial

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