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SRP3124

Sigma-Aldrich

Neurturin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

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Synonym(s):
NRTN, NTN

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

11.8 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NRTN(4902)

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Neurotrophin-3 human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

>97% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized powder

packaging

pkg of 20 μg

packaging

pkg of 20 μg

packaging

pkg of 20 μg

packaging

pkg of 5 μg

General description

Neurturin (NTN) is a disulfide-linked homodimer neurotrophic factor structurally related to glial cell derived neurotrophic factor (GDNF), artemin, and persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Biochem/physiol Actions

Neurturin (NTN) signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. NTN modulates spermatogenesis, kidney morphogenesis and controls smooth muscle of penile blood vessels and several intrapelvic organs.

Sequence

MARLGARPCG LRELEVRVSE LGLGYASDET VLFRYCAGAC EAAARVYDLG LRRLRQRRRL RRERVRAQPC CRPTAYEDEV SFLDAHSRYH TVHELSAREC ACV

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 4.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Novel functions and signalling pathways for GDNF
Hannu Sariola and Mart Saarma
Journal of Cell Science. Supplement, 116 (2003)
Neurotrophic factors and their effects in the treatment of multiple sclerosis
Shahnaz R
Advanced Biomedical Research (2015)
Neurturin has multiple neurotrophic effects on adult rat sacral parasympathetic ganglion neurons.
Yewlan Wanigasekara and Janet R Keast
The European Journal of Neuroscience, 22 (2005)
Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat
Laurikainen
Journal of Neurobiology, 43 (2000)
Hendrik Lehnert
Pathophysiology of Haemostasis and Thrombosis (2004)

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