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SRP3320

Sigma-Aldrich

IL-36RA human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

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Synonym(s):
FIL1 delta, IL-1F5, IL-1HY1, IL-1L1
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

17.0 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL36RN(26525)

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This Item
SRP3289SRP6199SRP8035
Sigma-Aldrich

SRP3320

IL-36RA human

Sigma-Aldrich

SRP3289

IL-36 GAMMA human

Sigma-Aldrich

SRP6199

IL-36β human

Sigma-Aldrich

SRP8035

IL-36α mouse

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

>95% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

mouse

mol wt

17.0 kDa

mol wt

17.0 kDa

mol wt

17.3 kDa

mol wt

~17 kDa

form

lyophilized

form

lyophilized

form

lyophilized powder

form

lyophilized

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36? (IL-1F6), IL-36? (IL-1F8), and IL-36? (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36?, -? or -? by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.

Biochem/physiol Actions

The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36? (IL-1F6), IL-36? (IL-1F8), and IL-36? (IL-1F9). Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jennifer E Towne et al.
The Journal of biological chemistry, 286(49), 42594-42602 (2011-10-04)
IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36Ra (formerly IL-1F5) has been reported to antagonize IL-36γ. However, our previous attempts to demonstrate

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