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SRP4928

Sigma-Aldrich

Lipocalin-2 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

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Synonym(s):
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

~20 kDa

packaging

pkg of 50 μg

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... LCN2(3934)

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This Item
AB2267SRP3049SAB2500595
vibrant-m

SRP4928

Lipocalin-2 human

vibrant-m

AB2267

Anti-LCN2 Antibody

vibrant-m

SRP3049

GDF-2 human

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

-

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

-

recombinant

expressed in E. coli

recombinant

-

recombinant

expressed in CHO cells

recombinant

-

mol wt

~20 kDa

mol wt

-

mol wt

24.1 kDa

mol wt

-

form

lyophilized

form

-

form

lyophilized

form

buffered aqueous solution

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

General description

The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34. LCN2, a secreted glycoprotein, is an adipokine. It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells and cardiomyocytes. LCN2 belongs to the lipocalin family. The recombinant human Lipocalin-2 consisting of 178 amino acids (a.a. 21-198, Accession# NP_00555) was expressed from Escherichia coli and purified using proprietary technology.

Application

LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.

Biochem/physiol Actions

LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation. LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. It is an early marker of acute kidney injury. LCN2 is upregulated in humans with heart failure. It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability. Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder and kidney cancers.

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B
Scientific Reports, 4, doi: 10-doi: 10 (2014)
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure.
Tawfeek MS
Therapeutic Advances in Cardiovascular Disease, 10, 30-36 (2016)
Dinna N Cruz et al.
Clinical chemistry and laboratory medicine, 54(2), 353-362 (2015-06-19)
Early biomarkers for acute kidney injury (AKI) diagnosis are needed since an increase in serum creatinine levels is a late marker. Neutrophil gelatinase-associated lipocalin (NGAL) is one of the most promising AKI biomarkers. Prior to routine clinical use, it is

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