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T1573

Sigma-Aldrich

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonym(s):

TRAP-6

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About This Item

Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
Molecular Weight:
748.87
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

>95% (HPLC)

form

lyophilized

technique(s)

cell culture | mammalian: suitable

solubility

0.1% TFA: soluble
water: soluble

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

Gene Information

human ... F2R(2149)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

Other Notes

Lyophilized from 0.1% TFA in H2O

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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