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V4890

Sigma-Aldrich

Vindesine sulfate salt hydrate

≥95% (HPLC)

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Synonym(s):
3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate salt hydrate, Desacetylvinblastine amide sulfate salt hydrate
Empirical Formula (Hill Notation):
C43H55N5O7 · H2SO4 · xH2O
CAS Number:
Molecular Weight:
852.00 (anhydrous basis)
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥95% (HPLC)

form

powder

color

off-white to light yellow

solubility

deionized water: ≥50 mg/mL

originator

Eli Lilly

storage temp.

−20°C

SMILES string

O.OS(O)(=O)=O.CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@H]7[C@](O)([C@H](O)[C@]8(CC)C=CC[N@H]9CC[C@]67[C@H]89)C(N)=O)C1

InChI

1S/C43H55N5O7.H2O4S.H2O/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4;/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4);1H2/t25-,34+,35-,36-,39+,40-,41-,42+,43+;;/m1../s1

InChI key

TUDLKTILIBRXNU-RIHOAIHNSA-N

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This Item
V1377H8759Q1250
Vindesine sulfate salt hydrate ≥95% (HPLC)

V4890

Vindesine sulfate salt hydrate

Vinblastine sulfate salt ≥97% (HPLC)

V1377

Vinblastine sulfate salt

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

deionized water: ≥50 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

solubility

H2O: slightly soluble 1.2 mg/mL, ethanol: 8 mg/mL

color

off-white to light yellow

color

white to light yellow

color

off-white

color

-

originator

Eli Lilly

originator

Eli Lilly

originator

-

originator

Bayer

Biochem/physiol Actions

Microtubule inhibitor. Vindesine binds to and stabilizes tubulin, thereby preventing tubulin polymerization, preventing mitosis, and arresting cells in metaphase.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Katrin Patrij et al.
German medical science : GMS e-journal, 9, Doc11-Doc11 (2011-06-24)
We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin's lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003-12/2007 were included into this analysis.
René-Olivier Casasnovas et al.
Blood, 118(1), 37-43 (2011-04-27)
The prognostic value of interim positron emission tomography (PET) interpreted according to visual criteria is a matter of debate in diffuse large B-cell lymphoma (DLBCL). Maximal standardized uptake value reduction (ΔSUVmax) may better predict outcome. To compare the prognostic value
François Lefrère et al.
Transfusion, 53(1), 115-122 (2012-05-09)
The ACVBP regimen is an efficient induction regimen for poor-risk patients with diffuse large B-cell lymphoma (DLBCL) before consolidative autologous stem cell transplantation. Adjunction of the monoclonal anti-CD20 antibody rituximab (R-ACVBP) was recently found to be superior to ACVBP alone.
Nagio Takigawa et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(6), 1087-1091 (2011-03-19)
Thoracic radiotherapy (RT) with concurrent chemotherapy may be offered to selected elderly patients with locally advanced non-small cell lung cancer. The Okayama Lung Cancer Study Group (OLCSG) 0007 trial with patients up to 75 years showed that with concurrent RT
N Ketterer et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 24(4), 1032-1037 (2012-12-14)
The superiority of a chemotherapy with doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP) in comparison with cyclophosphamide, doxorubicin, vincristin and prednisone plus radiotherapy for young patients with localized diffuse large B-cell lymphoma (DLBCL) was previously demonstrated. We report the results

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