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58151AST

CHIRALPAK® AGP HPLC Column

5 μm particle size, L × I.D. 15 cm × 4 mm

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eCl@ss:
32110501
NACRES:
SB.52

material

stainless steel column

Quality Level

agency

suitable for USP L41

product line

CHIRALPAK®

packaging

pkg of 1 ea

manufacturer/tradename

CHIRALPAK®

parameter

137 bar pressure (2000 psi)
20-30 °C temperature
40 °C max. temp.

technique(s)

HPLC: suitable

L × I.D.

15 cm × 4 mm

matrix

fully porous particle

matrix active group

glycoprotein, alpha1- phase

particle size

5 μm

operating pH

2-8

separation technique

chiral

storage temp.

2-8°C

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vibrant-m

58151AST

CHIRALPAK® AGP HPLC Column

Supelco

58130AST

CHIRALPAK® AGP HPLC Column

Supelco

58131AST

CHIRALPAK® AGP HPLC Column

Supelco

58150AST

CHIRALPAK® AGP HPLC Column

separation technique

chiral

separation technique

chiral

separation technique

chiral

separation technique

chiral

matrix active group

glycoprotein, alpha1- phase

matrix active group

glycoprotein, alpha1- phase

matrix active group

glycoprotein, alpha1- phase

matrix active group

glycoprotein, alpha1- phase

particle size

5 μm

particle size

5 μm

particle size

5 μm

particle size

5 μm

product line

CHIRALPAK®

product line

CHIRALPAK®

product line

CHIRALPAK®

product line

CHIRALPAK®

agency

suitable for USP L41

agency

suitable for USP L41

agency

suitable for USP L41

agency

suitable for USP L41

General description

Hermansson described the use of natural proteins immobilized onto a silica support for chiral separations in 1983 (1). Proteins contain a large number of chiral centers of one configuration, and many other sites that contribute to the general retention process. CHIRALPAK AGP has the broadest range of selectivity of all protein phases currently available. CHIRALPAK AGP phase uses α1-acid glycoprotein (AGP) as the chiral selector immobilized on spherical 5 μm silica particles. Bonded AGP is a very stable protein that tolerates pure organic solvents, elevated temperatures and pH values from 4 to 7. Operated in reversed-phase mode, CHIRALPAK AGP column separates enantiomers of an extremely broad range of drug substances, such as acids, amines and neutral compounds. The enantioselectivity and retention can easily be regulated by mobile phase pH and ionic strength, and the nature and concentration of the organic modifier.

Features:

  • Direct reversed phase resolution of chiral molecules
  • Stable with a variety of organic modifiers
  • Available in analytical and semi-preparative sizes

(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.

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Legal Information

CHIRALPAK is a registered trademark of Daicel Corp.

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