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HPLC Analysis of 1-Aminoindan Enantiomers on LARIHC CF6-P

application for HPLC

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HPLC: suitable

test parameters

column: LARIHC CF6-P, 25 cm x 4.6 mm I.D., 5 μm particles (AZYP Part No.L1001, available from Supelco/Sigma-Aldrich as a custom item)
mobile phase: [A] methanol: [B] acetonitrile: [C] acetic acid: [D] triethylamine, (70:30:, A:B:C:D)
flow rate: 1 mL/min
column temp.: 20 °C
detector: UV, 254 nm
injection: 5 μL
sample: 1-Aminoindan, 0.3 mg/mL in ethanol


application for HPLC


forensics and toxicology
pharmaceutical (small molecule)

General description

Cyclofructans are cyclic oligosaccharides and the newest class of chiral stationary phases for HPLC, SFC, and HILIC. Invented by Prof. Daniel W. Armstrong and introduced by AZYP, LLC, the LARICH and FRULIC derivatized cyclofructan-based columns are now available through Supelco/Sigma-Aldrich. The LARIHC CF6-P chiral stationary phase (CSP) was developed as an alkyl derivatized cyclofructan 6 chiral stationary phase. It has demonstrated pronounced enantioselectivity toward all types of primary amines, such as amino alcohols, amino esters, and amino amides. Baseline separation was achieved for simple aliphatic racemic amines that contained no other functionality. Unlike all current crown ether chiral stationary phases, this new column works more effectively with organic solvents and supercritical fluids. It also appears to have great capabilities for preparative-scale separations. No other existing phase can efficiently separate primary amines as well as the LARIHC CF6-P phase. A recent study showed that this phase alone can separate 93% of tested racemic primary amines.

Legal Information

LARIHC is a trademark of AZYP, LLC



    1-Aminoindan, 98%


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Ping Sun et al.
Analytical chemistry, 81(24), 10215-10226 (2009-12-17)
An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic- and aromatic-functionalized CF6s possess unique and very different
Ping Sun et al.
Journal of chromatography. A, 1217(30), 4904-4918 (2010-06-22)
A new chiral stationary phase (CSP) was developed by bonding isopropyl-carbamate functionalized cyclofructan6 (IP-CF6) to the silica gel. It was evaluated by injecting 119 racemic primary amine-containing compounds. This CSP showed pronounced enantioselectivity toward all types of primary amines, separating

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