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Nucleosil® C18 HPLC Column

3 μm particle size, L × I.D. 10 cm × 4.6 mm

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suitable for USP L1

Quality Level

product line






extent of labeling

15% Carbon loading


≤70 °C temp. range
400 bar pressure (5801 psi)


HPLC: suitable

L × I.D.

10 cm × 4.6 mm

surface area

350 m2/g



matrix active group

C18 (octadecyl) phase

particle size

3 μm

pore size

100 Å

separation technique

reversed phase

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Related Categories


  • Purification and Product Characterization of Lipoxygenase from Opium Poppy Cultures (Papaver somniferum L.).: This research focused on the purification and characterization of lipoxygenase from opium poppy cultures using HPLC with a Nucleosil® C18 column. The study provided detailed insights into the enzyme′s properties and potential applications in pharmaceutical industries (Holková et al., 2019).

  • A Rapid Stability-Indicating RP-HPLC Method for the Determination of Betaxolol Hydrochloride in Pharmaceutical Tablets.: The study developed a rapid, stability-indicating reverse-phase HPLC method for determining betaxolol hydrochloride in tablets using a Nucleosil® C18 column. The method was validated for its accuracy, precision, and robustness (Auvity et al., 2013).

  • Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection.: This study developed a novel HPLC method with a Nucleosil® C18 column for the simultaneous determination of six metabolites of L-tryptophan, providing a comprehensive approach to studying melatonin synthesis in the gastrointestinal tract (Zagajewski et al., 2012).

  • Development and validation of an HPLC-method for determination of free and bound phenolic acids in cereals after solid-phase extraction.: The research presented a validated HPLC method using a Nucleosil® C18 column for determining phenolic acids in cereals. The method included solid-phase extraction, ensuring high sensitivity and specificity for both free and bound phenolic acids (Irakli et al., 2012).

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Legal Information

Nucleosil is a registered trademark of Macherey-Nagel GmbH & Co. KG

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