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1044006

USP

Aspirin

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
Molecular Weight:
180.16
Beilstein:
779271
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

aspirin

manufacturer/tradename

USP

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

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This Item
Y0001460PHR1003BP617
Aspirin United States Pharmacopeia (USP) Reference Standard

USP

1044006

Aspirin

Aspirin British Pharmacopoeia (BP) Reference Standard

BP617

Aspirin

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

BP

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

format

neat

format

neat

format

neat

format

neat

API family

aspirin

API family

aspirin

API family

aspirin

API family

aspirin

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aspirin USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard solution for impurity analysis and performance test according to the given below monographs of United States Pharmacopeia (USP):
  • Carisoprodol and Aspirin Tablets.
  • Aspirin Tablets.
  • Aspirin Boluses.
  • Butalbital, Aspirin, Caffeine, and Codeine Phosphate Capsules.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

482.0 °F

Flash Point(C)

250 °C


Certificates of Analysis (COA)

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25G
Pack Size/Quantity

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Butalbital, Aspirin, Caffeine, and Codeine Phosphate Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(2), 648-648 (2013)
Aspirin Boluses
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 388-388 (2017)
Carisoprodol and Aspirin Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 778-778 (2013)
Aspirin Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 392-392 (2020)
Martine Gilard et al.
Journal of the American College of Cardiology, 65(8), 777-786 (2014-12-03)
The currently recommended duration of dual antiplatelet therapy (DAPT) in drug-eluting stent (DES) recipients is 12 months to reduce the risk of late stent thrombosis, particularly in those with acute coronary syndrome (ACS). This study hypothesized that antiplatelet treatment with DAPT

Protocols

HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

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