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Key Documents

1154569

USP

Beta Cyclodextrin

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

β-Cyclodextrin, Caraway, Cycloheptaamylose, Cyclomaltoheptaose, Schardinger β-Dextrin

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About This Item

Empirical Formula (Hill Notation):
C42H70O35
CAS Number:
Molecular Weight:
1134.98
Beilstein/REAXYS Number:
78623
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

plant

grade

pharmaceutical primary standard

optical activity

[α]20/D +162±3°, c = 1.5% in H2O

analyte chemical class(es)

oligosaccharides

manufacturer/tradename

USP

mp

290-300 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]1[C@H](O)[C@H]2O

InChI

1S/C42H70O35/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51/h8-63H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m1/s1

InChI key

WHGYBXFWUBPSRW-FOUAGVGXSA-N

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General description

Betadex is a nonreducing cyclic compound composed of seven alpha-(1–4) linked d-glucopyranosyl units.

Application

Beta Cyclodextrin USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard and system suitability solution for the assay and impurity analysis by using liquid chromatography coupled with Refractive index detector according to the below monographs of United States Pharmacopeia (USP) :

  • Betadex
  • Alfadex

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

related product

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Betadex
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 31(1) (2020)
Alfadex
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 34(1) (2020)
Nuclear magnetic resonance methods for high molecular weight proteins: a study involving a complex of maltose binding protein and beta-cyclodextrin.
L E Kay
Methods in enzymology, 339, 174-203 (2001-07-21)
H Chen et al.
Se pu = Chinese journal of chromatography, 17(6), 533-538 (2003-01-30)
A review of beta-cyclodextrin bonded stationary phases in chiral liquid chromatography is given, focusing on design and synthesis of beta-cyclodextrin bonded chiral stationary phases. Fifty-three references are presented in this paper.
Golfo G Kordopati et al.
Biochimica et biophysica acta, 1850(1), 159-168 (2014-12-03)
Cyclodextrins (CDs) in combination with therapeutic proteins and other bioactive compounds have been proposed as candidates that show enhanced chemical and enzymatic stability, better absorption, slower plasma clearance and improved dose-response curves or immunogenicity. As a result, an important number

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