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Sterile Filters

Sterile drug product

Sterile filtration is an important step in the drug production process and is routinely implemented for bacterial removal throughout bioprocessing to achieve bioburden control.


For sterile filtration of aqueous liquids, we offer filters containing Durapore® polyvinylidene fluoride (PVDF) membranes and Millipore Express® filters containing polyethersulfone (PES) membranes. For sterile filtration of non-aqueous liquids, polytetrafluoroethylene (PTFE) membranes are available.

Selecting the right filter

Choosing the right sterilizing filter and device format for the process step or application is key to developing an efficient, cost-effective process. You can be confident our filter portfolio encompasses the standard-setting products your work deserves.
Filter selection is dependent on the feed characteristics and particulate levels, the level of contamination risk, and the specific process step. For critical aseptic processing operations, sterilizing-grade filters are the preferred solution. For non-critical or “low risk” operations such as buffer filtration and column protection, bioburden reduction filters may be used.

  • All filters are fully scalable from small-scale tools to pilot and production-scale manufacturing
  • Most are offered as single-use capsules or cartridge filters
  • For plugging streams, high-area formats double the membrane area, without increasing filter footprint
  • Filters are offered in autoclavable, gamma-compatible or pre-sterilized formats with different connection options

Regulatory Compliance

Complementing our product portfolio, the Emprove® Program consolidates comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

Related Product Resources

Product Selection

Brochure: Mission Control: Strategies for Effective Bioburden and Aseptic Control
Tech Bulletin: Extended Bacterial Retention Testing of Millipore Express® 0.2 μm Filters in a Continuous Flow System
Webinar: Selection, Sizing, and Operation of Bioprocess Filtration Trains for Optimal Performance
Webinar: Find Your Filter – Which Aseptic Filter is Best for Your Process?
Webinar: Strategies to Address Bioburden Control in Downstream Processing
Webinar: Does Your SVP Process Assure Sterile Drug Product?
Webinar: Defining a Strategy for the Validation and Qualification of Sterile Filtration Processes for Investigational Medicinal Compounds
Webinar: Scale-up of High-Area Filters for Microfiltration of Biological Fluids

Product Operations

Tech Bulletin: Integrity Test Troubleshooting – Beyond Rewet and Retest
Tech Bulletin: Establishing Product Specific Bubble Point Specifications for Sterilizing Grade Filters
Webinar: Filter Integrity Testing Best Practices
Webinar: Potential Impact of Draft Annex 1 on Sterilizing Filtration

Product Specifications

Durapore® Family Guide
Millipore Express® Family Guide
Solvex™ Solvent Filtration Cartridge Filters

Products

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Product Number
Product Description
Pricing
MPGL02GH2
Millipak®-20 Capsule Filter Unit, sterile
MPGL02GF2
Millipak®-20 Capsule Filter Unit, sterile
CVDI73TPE
Durapore® CVDI Cartridge Filter, pore size 0.2 μm, cartridge nominal length 30 in. (75 cm), Code 7 (2-226; O-rings w/locking-tabs)
KHGEA10HH1
Opticap® Autoclavable XL 10 Millipore Express® SHC 0.5/0.2 m 9/16 in. HB/HB, inlet connection diam. 9/16 in., pore size 0.5/0.2 μm, cartridge nominal length 10 in. (25 cm)
KHGES03HH3
Opticap® XL3 Millipore Express® SHC, sterile, inlet connection diam. 9/16 in., pore size 0.5/0.2 μm, cartridge nominal length 3 in. (7.5 cm)
KHGEG3TTT1H
Opticap® Gamma Compatible XLT Capsule Filter, cartridge nominal length 30 in. (75 cm)
MPGL1GCA3
Millipak®-100 Capsule Filter Unit, sterile
MCGBL4S03
Millidisk® Barrier Filter 0.22 µm hydrophilic/phobic
CVDI73TPS
Durapore® CVDI Cartridge Filter, pore size 0.2 μm, cartridge nominal length 30 in. (75 cm), Code 7 (2-226; O-rings w/locking-tabs)
MPGL2GCL3
Millipak®-200 Capsule Filter Unit, sterile
MTGR85010
Aervent® Capsule Filter, pore size 0.2 μm
KVGLS10HH1
Opticap® XL10 Durapore®, sterile, inlet connection diam. 9/16 in., cartridge nominal length 10 in. (25 cm)
MPGL1GCF3
Millipak®-100 Capsule Filter Unit, sterile
CVGB71TP
Durapore® CVGB Cartridge Filter, pore size 0.22 μm, Code 7
KHVEA03HH3
Opticap® XL3 Millipore Express® SHR with Prefilter, inlet connection diam. 9/16 in., pore size 0.5/0.1 μm, cartridge nominal length 3 in. (7.5 cm)
KHGEA10TH1
Opticap® XL10 Millipore Express® SHC, inlet connection diam. 1.5 in., pore size 0.5/0.2 μm, cartridge nominal length 10 in. (25 cm)
KHGES003HH3
Opticap® XL300 Millipore Express® SHC, sterile, outlet connection diam. 9/16 in., pore size 0.5/0.2 μm, cartridge nominal length 4.7 in. (11.9 cm)
KTGRA04TT3
Opticap® XL Aervent®, inlet connection diam. 1.5 in., pore size 0.2 μm, cartridge nominal length 7.7 in. (19.6 cm)
MPHL02GH2
Millipak®-20 Capsule Filter Unit, sterile
MPGL2GCF3
Millipak®-200 Capsule Filter Unit, sterile
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Highlights

Find Your Filter – Which Aseptic Filter is Best for Your Process?
Find Your Filter – Which Aseptic Filter is Best for Your Process?

This webinar summarizes filter design, criteria for filter selection, and how new filter choices can maximize your productivity. 

Selection, sizing, and operation of bioprocess filtration trains for optimal performance
Selection, sizing, and operation of bioprocess filtration trains for optimal performance

A model and test methodology are described for rapidly and efficiently determining an optimal prefilter and final filter system design for filtration of bioprocess fluids.

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