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Showing 1-30 of 58 results for "00010" within Papers
Nature communications, 11(1), 1458-1458 (2020-03-21)
Esterification reactions are central to many aspects of industrial and biological chemistry. The formation of carboxyesters typically occurs through nucleophilic attack of an alcohol onto the carboxylate carbon. Under certain conditions employed in organic synthesis, the carboxylate nucleophile can be
Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.
Molecular cancer therapeutics, 13(10), 2328-2340 (2014-08-02)
Malignant melanoma is a difficult cancer to treat due to the rapid development of resistance to drugs targeting single proteins. One response to this observation is to identify single pharmacologic agents that, due to a unique mechanism of action, simultaneously
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(1), 57-59 (2013-04-20)
To develop an HPLC method for content determination of dehydroabietic acid and abietic acid in aqueous alkali extract of Liquidambaris Resina. The determination was carried out on a DIONEX C18 column (4.6 mm x 250 mm, 5 microm) eluted with
Applied microbiology and biotechnology, 97(17), 7639-7649 (2013-06-25)
Cytochrome P450 enzymes exhibit a tremendous potential for biotechnological applications due to their ability to introduce oxygen into non-activated carbon atoms. Their catalytic diversity is complemented by a broad substrate range covering many natural compounds. Especially the functionalization of terpenoids
Biochemistry, 56(24), 2995-3007 (2017-06-02)
FtmPT1 is a fungal indole prenyltransferase that affords Tryprostatin B from Brevianamide F and dimethylallyl pyrophosphate; however, when a single residue in the active site is mutated (Gly115Thr), a novel five-membered ring compound is obtained as the major product with
Journal of bacteriology, 190(5), 1575-1583 (2007-12-25)
The 80-kb dit cluster of Burkholderia xenovorans LB400 encodes the catabolism of abietane diterpenoids. This cluster includes ditQ and ditU, predicted to encode cytochromes P450 (P450s) belonging to the poorly characterized CYP226A subfamily. Using proteomics, we identified 16 dit-encoded proteins
The Journal of toxicological sciences, 44(9), 585-600 (2019-09-03)
Amino acid derivative reactivity assay (ADRA) has previously been developed as an alternative method to direct peptide reactivity assay (DPRA) to evaluate key event 1 in skin sensitization mechanisms. However, when using alternative methods for skin sensitization, integrated approaches to
Chemistry & biodiversity, 10(2), 198-208 (2013-02-19)
Hexane extracts of needles and defoliated twigs of Pinus pumila (Pall.) Regel from two distant populations, located in the southwest and the east (i.e., Lake Baikal region and Sakhalin Island) of the species distribution range were studied by GC/MS analysis.
Journal of environmental monitoring : JEM, 10(3), 345-352 (2008-04-09)
The purpose of this study was to develop a sensitive and specific method for quantifying dermal exposure to the resin acids 7-oxodehydroabietic acid (7-OXO), dehydroabietic acid (DHAA), abietic acid (AA), and pimaric acid (PA). In addition the method was evaluated
Physical chemistry chemical physics : PCCP, 15(16), 5898-5915 (2013-03-15)
The reactive uptake coefficients (γ) of OH by levoglucosan, abietic acid, and nitroguaiacol serving as surrogate compounds for biomass burning aerosol have been determined employing a chemical ionisation mass spectrometer coupled to a rotating-wall flow-tube reactor over a wide range
Chemical composition of natural colophony from Pinus brutia and comparison with synthetic colophony.
Natural product communications, 5(11), 1729-1732 (2011-01-11)
The compositions of colophony resins obtained from Pinus brutia Ten trees by three different methods (acid paste, carved hole and scraping) from Ayvacik, Gökova and Kemalpaşa in Turkey were analyzed by capillary GC-MS. The main components were the monoterpenes alpha-pinene
Regulatory toxicology and pharmacology : RTP, 107, 104401-104401 (2019-06-04)
The local lymph node assay using 5-bromo-2-deoxyuridine with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA used to identify skin sensitizers. This assay measures the proliferation of auricular lymph node cells (LNCs) during the induction phase of skin sensitization and
Plant, cell & environment, 43(8), 1827-1843 (2020-04-24)
In response to various stimuli, plants acquire resistance against pests and/or pathogens. Such acquired or induced resistance allows plants to rapidly adapt to their environment. Spraying the bark of mature Norway spruce (Picea abies) trees with the phytohormone methyl jasmonate
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 26(4), 568-573 (2009-08-15)
Abietic acid (AA) and dehydroabietic acid (DHA) have been detected in virgin paper products and recycled paper products used for food packaging. In order to evaluate the cell transformation activities of AA and DHA, the Bhas 42 cell-transformation assay for
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 127, 110155-110155 (2020-05-16)
Dual-PPAR-α/γ agonist has the dual potentials to improve insulin resistance (IR) and hepatic steatosis associated with obesity. This study aimed to investigate whether dehydroabietic acid (DA), a naturally occurred compound, can bind to and activate both PPAR-γ and PPAR-α to
Synthesis of biobased epoxy and curing agents using rosin and the study of cure reactions.
Green Chemistry, 10(11), 1190-1196 (2008)
Regulatory toxicology and pharmacology : RTP, 108, 104473-104473 (2019-09-09)
In the last 20 years, alternative approaches to the identification of skin sensitisation hazards have been at the forefront of the 3Rs and have helped refine the validation and acceptance processes. However, experience with the local lymph node assay showed
Rosin-derived imide-diacids as epoxy curing agents for enhanced performance.
Bioresource Technology, 101(7), 2520-2524 (2010)
Chembiochem : a European journal of chemical biology, 12(4), 576-582 (2011-01-29)
The cytochrome P450 monooxygenase CYP106A2 from Bacillus megaterium ATCC 13368 catalyzes hydroxylations of a variety of 3-oxo-Δ(4) -steroids such as progesterone and deoxycorticosterone (DOC), mainly in the 15β-position. We combined a high-throughput screening and a rational approach for identifying new
Synthesis of (+)-amberketal and its analog from L-abietic acid.
Tetrahedron, 63(39), 9896-9902 (2007)
Bioresource technology, 129, 58-64 (2012-12-13)
A novel chiral monomer N-propargyl abietamide, M1, was synthesized from abietic acid and catalytically polymerized with (nbd)Rh+B-(C6H5)4 (nbd=norbornadiene), providing polymer [poly(1)] with a molecular weight of 13,000-36,000 at a yield of 59-84%. Poly(1) did not form stable helices in tetrahydrofuran
Odontology, 108(1), 57-65 (2019-09-15)
Dental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and lifetime use as anti-oral infection agents. This study aimed to
Journal of chromatography. A, 1371, 20-29 (2014-12-03)
Two resin acids, abietic acid (AA) and dehydroabietic acid (DHAA), in cosmetics may cause allergy or toxicoderma, but remain inaccurately investigated due to their lability. In this work, an accurate, sensitive, efficient and convenient method, utilizing the ultrasonic-assisted closed in-syringe
Allergic contact dermatitis from depilatory wax.
Dermatitis : contact, atopic, occupational, drug, 23(3), 126-127 (2012-06-02)
European journal of medicinal chemistry, 44(6), 2468-2472 (2009-02-17)
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid
Isolation, chemical, and biotransformation routes of labdane-type diterpenes.
Chemical reviews, 111(8), 4418-4452 (2011-05-31)
Journal of the American Chemical Society, 133(21), 8335-8343 (2011-05-10)
Abietic acid, a constituent of pine resin, is naturally derived from abietadiene --a process that requires four enzymes: one (abietadiene synthase) for conversion of the acyclic, achiral geranylgeranyl diphosphate to the polycyclic, chiral abietadiene (a complex process involving the copalyl diphosphate
Cytotoxic, immunomodulatory, antimycotic, and antiviral activities of semisynthetic 14-hydroxyabietane derivatives and triptoquinone C-4 epimers
MedChemComm, 4(9), 1239-1246 (2013)
Tetrahedron Letters, 23, 1087-1087 (1982)
Phytochemistry, 150, 31-39 (2018-03-14)
Wood extractives in the xylem of European larch Larix decidua were mapped by time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging, which allows the radial distribution of both mineral and lipophilic extractives in the xylem to be scrutinized with high spatial
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