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Showing 1-30 of 34 results for "00370580" within Papers
Jiaying Wu et al.
Neurochemistry international, 62(1), 92-102 (2012-10-16)
Ginsenoside Rg1, a steroidal saponin of high abundance in ginseng, possesses the neuroprotective effects. In this study, we tried to explore the effect of Rg1 on promoting differentiation of mouse embryonic stem (ES) cells towards the neuronal lineage and its
Bohyoung Lee et al.
Journal of chromatographic science, 52(6), 482-492 (2013-06-07)
Palmul-tang, a traditional herbal medicine, is composed of eight herbs (Ginseng radix, Glycyrrhizae radix, Hoelen, Atractylodis rhizoma, Angelicae gigantis radix, Cnidii rhizoma, Paeoniae radix and Rehmanniae radix) and exhibits various bioactivities, including antiallergic and antitumor effects. In this study, an
Xiaoduo Guan et al.
Journal of pharmaceutical and biomedical analysis, 72, 261-266 (2012-09-27)
A simple and rapid high performance liquid chromatography electrospray ionization ion-trap tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantitative determination of esculentoside A (EsA) in dog plasma using ginsenoside Rg1 as the internal standard (IS).
Jin-Kwang Kim et al.
Journal of biotechnology, 161(3), 294-301 (2012-07-07)
This study focuses on the cloning, expression, and characterization of recombinant ginsenoside hydrolyzing glycosidase from Sanguibacter keddieii in order to biotransform ginsenosides efficiently. The gene, termed bglSk, consists of 1857 bp and revealed significant homology to that of glycoside hydrolase
Yue Zhou et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(17), 2848-2853 (2014-01-02)
To investigate the anti-aging effect of ginsenoside R1 in serial transplantation of hematopoietic stem cells and progenitor cells. HSC/HPC aging model in vivo was established through the Sca-1 (+) HSC/HPC serial transplantation of male donor mice that had been separated
Ying-Hong Jiang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3477-3480 (2013-02-05)
To observe the effects of ginsenoside Rg1 on the functional expression of human neural stem cells (hNSCs). The membrane electrophysiological properties and sodium and potassium ion channels in the hNSCs induced by Rg1 were analyzed using the whole-cell patch-clamp. On
Mei Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(12), 1747-1750 (2012-09-25)
To investigate targeted distribution of ginsenoside Rg1 in mice tissues before and after modification by the PEG. SD mice were randomly divided into two groups and given Rg1 and PEG-Rg1 by intravenous injection respectively. Their samples of blood and organ
Y Takino
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 114(8), 550-564 (1994-08-01)
The pharmacodynamics of ginsenoside-Rg1 (Rg1), -Rb1 (Rb1) and -Rb2 (Rb2) in rats were studied. In these studies, obvious differences were found in their pharmacodynamics. That is, Rg1 was easily hydrated to the same prospogenins in both rat stomach and 0.1
P Wang et al.
Australian dental journal, 57(2), 157-165 (2012-05-26)
Human dental pulp cells (hDPCs) have the potency to proliferate and differentiate into odontoblasts and play an important role in dentine formation and reparation. The aim of the present study is to evaluate the effects of ginsenoside Rg1 on the
QianKun Quan et al.
PloS one, 8(3), e59155-e59155 (2013-03-23)
The present study was designed to examine the effects of ginsenoside Rg1 on expression of peroxisome proliferator-activated receptor γ (PPARγ) and insulin-degrading enzyme (IDE) in the hippocampus of rat model of Alzheimer's disease (AD) to determine how ginsenoside Rg1 (Rg1)
Yingbo Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(4), 509-514 (2012-06-07)
To observe the effect of Rg1-induced NSCs in treatment of neonatal rat model with hypoxiaischemia. The neonatal rat model of HIE was established and assessed by using TTC staining and behavioral observation, then Rg1-induced NSCs was transplanted into the neonatal
Jung-Sun Cho et al.
Experimental biology and medicine (Maywood, N.J.), 237(6), 663-669 (2012-06-26)
Nasal polyps are associated with chronic inflammation of the sinonasal mucosa and are involved in myofibroblast differentiation and extracellular matrix (ECM) accumulation. Ginsenoside Rg1, a compound derived from Panax ginseng, shows antifibrotic and anticancer effects. However, the molecular effects of
Wei Li et al.
Brain research bulletin, 88(5), 501-506 (2012-05-24)
Excessive accumulation of amyloid-β (Aβ) has been proposed as a pivotal event in Alzheimer's disease (AD) pathogenesis. Possible mechanisms underlying Aβ-induced neurotoxicity include inflammation and apoptosis. Here, the protective effect of ginsenoside Rg1 (GRg1) on neuronal damage was examined in
Wei Li et al.
Life sciences, 91(15-16), 809-815 (2012-09-18)
In the present study we aimed to investigate the neuroprotective effect of ginsenoside Rg1 (GRg1) on neuronal damage examined in an adopted in vitro inflammatory neurodegeneration model and the involvement of p38 MAPK signal pathway. The supernatant from Aβ(1-40)-stimulated THP-1
Shizhong Cai et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(16), 2424-2428 (2012-12-14)
To observe the effect and mechanism of ginsenoside Rg1 in inducing senescence human leukemia K562 cell line. Proliferation of K562 cell line induced by Rg1 was detected by MTT colorimetric test for the purpose to screen optimal active concentration and
Fang Chen et al.
Biological & pharmaceutical bulletin, 35(9), 1568-1573 (2012-09-15)
Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside
Constance Lay Lay Saw et al.
Chemical research in toxicology, 25(8), 1574-1580 (2012-07-12)
Ginseng has long been used in Asian countries for more than 2000 years. Currently, in the "Western World or Western Medicines", many reports have indicated that they have used herbal medicines, and ginseng is one of the most popular herbs.
[Nootropic mechanisms of ginsenoside Rg1--influence on neuronal plasticity and neurogenesis].
Jun-tian Zhang
Yao xue xue bao = Acta pharmaceutica Sinica, 40(5), 385-388 (2005-10-14)
Jeonghyeon Kim et al.
International immunopharmacology, 14(4), 481-486 (2012-09-04)
Type-1 and -2 responses of T helper lymphocytes demonstrate essentially different and opposite effector functions. In the present study, we determined the immunoregulatory effect of ginsenoside Re against disseminated candidiasis due to Candida albicans. This fungus may be one of
Quan-Gui Gao et al.
The Journal of steroid biochemistry and molecular biology, 141, 104-112 (2014-02-11)
Recent studies indicated that both estren and Rg1 appear to be able to activate mitogen-activated protein kinase (MAPK) pathway in estrogen responsive cells. Rg1 could lead to MAPK activation through ligand-independent activation of estrogen receptor (ER), while estren could activate
Jiaying Wu et al.
Neuropharmacology, 63(3), 349-361 (2012-04-27)
Ginsenoside Rg1 (Rg1) acts as a neuroprotective agent against various insults, however, the underlying mechanism has not been fully elucidated yet. Here, we report that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide₂₅₋₃₅ (Aβ₂₅₋₃₅) injury via estrogen receptor α
Guang-Hui Zhang et al.
BMC genomics, 16, 159-159 (2015-03-15)
P. vietnamensis var. fuscidiscus, called "Yesanqi" in Chinese, is a new variety of P. vietnamensis, which was first found in Jinping County, the southern part of Yunnan Province, China. Compared with other Panax plants, this species contains higher content of
X Zhang et al.
Neuroscience, 220, 191-200 (2012-06-26)
Ginsenoside Rg1, which could improve spatial learning and memory, might be a useful agent for preventing and treating cognitive impairment in Alzheimer's disease (AD). The present study was designed to test the neuroprotective effects of ginsenoside Rg1 on an ovariectomized
Wen-Fang Chen et al.
Menopause (New York, N.Y.), 19(9), 1052-1061 (2012-05-03)
The present study was designed to determine whether ginsenoside Rg1 could exert selective estrogenic effects by using both cell lines and an animal model. The endometrial Ishikawa cells and preosteoblastic MC3T3-E1 cells were treated with a different dose of Rg1.
Naiquan Yang et al.
Acta biochimica et biophysica Sinica, 44(12), 999-1005 (2012-11-01)
Neovascularization and the formation of collateral vessels are often impaired in diabetes mellitus (DM) population compared with non-diabetics. Alterations in vascular endothelial growth factor (VEGF) signaling and endothelial nitric oxide synthase (eNOS) dysfunction have been confirmed to play a crucial
Cai-ping Li et al.
Environmental toxicology and pharmacology, 35(1), 21-29 (2012-12-12)
Ambient airborne particulate matter (PM) is an important environmental pollutant responsible for many human diseases. Oxidative stress is suggested to be involved in PM-induced cell injury. The present study is designed to study unsalutary effects of the organic extracts of
Jia-ying Wu et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 41(4), 393-401 (2012-08-29)
To assess the neuroprotective effects of ginsenoside Rg1 against β-amyloid peptide (Aβ(25-35))-induced apoptosis in primarily cultured rat cortical neurons. Primarily cultured cortical neurons were obtained from embryonic (E18d) rat fetus and maintained in neurobasal medium for 7d. Primary neurons pretreated
Mei Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(10), 1378-1382 (2012-08-07)
To study the stability of ginsenoside Rg1 before and after being modified by PEG (PEG-Rg1) in isolated rat stomachs. SD rats, after 18 h of fasting, were randomly divided into the Rg1 group and the PEG-Rg1 group. Rg1 stomach perfusion
Yong Cheng et al.
Acta pharmacologica Sinica, 26(2), 143-149 (2005-01-25)
In the present paper, we overview the discovery of new biological activities induced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure; especially Rg1, as one small molecular
Bei-Mei Zuo et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3706-3711 (2013-05-01)
To study cultivation of Panax ginseng adventitious roots in bubble bioreactors. The adventitious roots were obtained through tissue culture different types of bioreactors. The contents of ginsenosides Re, Rb1 and Rg1 were determined by HPLC while the contents of polysaccharides
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