Search Within
03440
Applied Filters:
Keyword:'03440'
Showing 1-30 of 102 results for "03440" within Papers
M Beyermann et al.
International journal of peptide and protein research, 37(4), 252-256 (1991-04-01)
The effect of tertiary amine (DIEA) on reaction rate and product purity of a carbodiimide/HOBt-mediated peptide synthesis was studied. It was found that very rapid activation can be achieved using carbodiimide/HOBt in non-polar solvents, such as DCM. Although the HOBt
Coralie Charrat et al.
Chembiochem : a European journal of chemical biology, 16(5), 792-804 (2015-02-18)
We describe the formulation of synthetic virus models based on ionic compounds bearing the polymerizable 1,2-dithiolane moiety. First, cationic amphiphiles containing the polymeric inducer were prepared and used to efficiently condense a DNA plasmid (pDNA) into a highly monodisperse population
Patrick J Stahl et al.
Analytical biochemistry, 424(2), 137-139 (2012-03-06)
Here we present a highly efficient protocol for on-the-resin coupling of fluorescent dyes or other functional groups to the N-termini of synthetic peptides prior to cleavage and deprotection. The protocol avoids expensive preactivated dyes and instead employs carboxylated dyes activated
Wen Shi et al.
Biomaterials, 35(22), 5760-5770 (2014-04-24)
N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, hinders the detection of resident or nearby metastatic lesions thereby decreasing diagnostic effectiveness. Our laboratory has
Palladium-Catalyzed Carbon- Sulfur Cross-Coupling Reactions with Indium Tri (organothiolate) and Its Application to Sequential One-Pot Processes
Lee J-Y and Lee PH
The Journal of Organic Chemistry, 73(18), 7413-7416 (2008)
Scott Boitano et al.
PloS one, 9(6), e99140-e99140 (2014-06-14)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to determine minimal
Ushasri Chilakamarthi et al.
Experimental cell research, 327(1), 91-101 (2014-06-08)
Targeted molecular imaging to detect changes in the structural and functional organization of tissues, at the molecular level, is a promising approach for effective and early diagnosis of diseases. Quantitative and qualitative changes in type I collagen, which is a
Akiyoshi Hirata et al.
Journal of the American Chemical Society, 136(32), 11546-11554 (2014-07-19)
A polyamide containing N-methylpyrrole (Py) and N-methylimidazole (Im), designated PIPA, binds with high affinity and specificity to specific nucleotide sequences in the minor groove of double-helical DNA. Based on a recent report of the synthesis of PIPA for telomere visualization
Seyedsina Moeinzadeh et al.
Tissue engineering. Part A, 21(1-2), 134-146 (2014-07-23)
An attractive approach to reduce the undesired side effects of bone morphogenetic proteins (BMPs) in regenerative medicine is to use osteoinductive peptide sequences derived from BMPs. Although the structure and function of BMPs have been studied extensively, there is limited
Carina S D Wink et al.
Analytical and bioanalytical chemistry, 407(6), 1545-1557 (2015-01-13)
Lefetamine (N,N-dimethyl-1,2-diphenylethylamine, L-SPA) was marketed as an opioid analgesic in Japan and Italy. After being widely abused, it became a controlled substance. It seems to be a pharmaceutical lead for designer drugs because N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA) were confiscated
Levente E Dókus et al.
European journal of medicinal chemistry, 82, 274-280 (2014-06-11)
Calpains are intracellular cysteine proteases with important physiological functions. Up- or downregulation of their expression can be responsible for several diseases, therefore specific calpain inhibitors may be considered as promising candidates for drug discovery. In this paper we describe the
Mingqian Tan et al.
Pharmaceutical research, 31(6), 1469-1476 (2013-03-09)
To synthesize and evaluate a peptide targeted nanoglobular dual modal imaging agent specific to a cancer biomarker in tumor stroma for MRI and fluorescence visualization of prostate tumor in image-guided surgery. A peptide (CGLIIQKNEC, CLT1) targeted generation 2 nanoglobular (polylysine
Nagappanpillai Adarsh et al.
Analytical chemistry, 86(18), 9335-9342 (2014-08-26)
With an objective to develop optical probes for biologically important anions and neutral molecules, we synthesized three novel NIR absorbing aza-BODIPY derivatives, 3a-3c, and have systematically tuned their photophysical properties by changing the peripheral substitution. A profound red-shift was observed
Claudia Scholz et al.
ChemMedChem, 9(9), 2104-2110 (2014-02-08)
The optimization of synthetic carriers for gene transfer remains a major challenge. Cationic polymers such as polyethylenimine (PEI) often show increasing gene transfer activity with increasing molecular weight, but this favorable effect is accompanied by an undesired increase in cytotoxicity.
Soo Min Cho et al.
Scientific reports, 4, 6777-6777 (2014-10-28)
Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of Alzheimer's disease (AD), the link
John R Horsley et al.
Journal of the American Chemical Society, 136(35), 12479-12488 (2014-08-15)
Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1-6) or β-strand (7-9) conformation, with variable numbers of electron rich alkene containing side chains. Peptides (1 and 2) and (7 and 8) are further constrained
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS
Evgeni Eltzov et al.
Analytical chemistry, 87(7), 3655-3661 (2015-03-17)
Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable
Jakeb M Reis et al.
Biochemistry, 53(30), 5008-5016 (2014-07-09)
The design of new optogenetic tools for controlling protein function would be facilitated by the development of protein scaffolds that undergo large, well-defined structural changes upon exposure to light. Domain swapping, a process in which a structural element of a
Baowei Yang et al.
Organic & biomolecular chemistry, 13(15), 4551-4561 (2015-03-18)
Three series of Momordica charantia (MC)2 analogues were designed, synthesized and evaluated for their anti-hyperglycaemic effects. Alanine scanning focusing on the peptide MC2 indicated the importance of the residues proline (Pro)(3), serine (Ser)(6), isoleucine (Ile)(7) and Ser(10) for anti-hyperglycaemic effects.
Lisa Pollaro et al.
Molecular cancer therapeutics, 14(1), 151-161 (2014-11-09)
Monoclonal antibodies have long in vivo half-lives and reach high concentrations in tumors but cannot access all regions in the tissue, whereas smaller ligands such as peptides distribute better but are limited by low concentrations due to fast renal clearance.
Linnea Olofsson et al.
Nature communications, 5, 5206-5206 (2014-10-18)
Efficient cell-to-cell communication relies on the accurate signalling of cell surface receptors. Understanding the molecular bases of their activation requires the characterization of the dynamic equilibrium between active and resting states. Here, we monitor, using single-molecule Förster resonance energy transfer
Emma-Dune Leriche et al.
Molecules (Basel, Switzerland), 19(12), 20731-20750 (2014-12-17)
Highly branched polyamidoamine (PAMAM) dendrimers presenting biological activities have been envisaged as non-viral gene delivery vectors. They are known to associate with nucleic acid (DNA) in non-covalent complexes via electrostatic interactions. Although their transfection efficiency has been proved, PAMAMs present
Yang Li et al.
Macromolecular bioscience, 15(1), 52-62 (2014-12-06)
To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged
Hyo Jin Kang et al.
Biosensors & bioelectronics, 67, 413-418 (2014-09-15)
Caspase-3 is an apoptotic cysteine protease and its aberrancy is highly implicated to numerous diseases thereby rendering caspase-3 activity as an important disease marker. Most caspase-3 sensors are caspase-3 substrates of which the fluorescence signals are turned on upon catalytic
Małgorzata Cebo et al.
Analytical and bioanalytical chemistry, 406(30), 8013-8020 (2014-10-31)
Isotope exchange at the histidine C2 atom of imidazole in D2O solution is well known to occur at a significantly slower rate than the exchange of amide protons. Analysis of the kinetics of this isotope-exchange reaction is proposed herein as
Junfeng Shi et al.
Biomacromolecules, 15(10), 3559-3568 (2014-09-18)
Peptides made of D-amino acids, as the enantiomer of corresponding L-peptides, are able to resist proteolysis. It is, however, unclear or much less explored whether or how D-amino acids affect the cellular response of supramolecular nanofibers formed by enzyme-triggered self-assembly
M Gomez-Mendoza et al.
Organic & biomolecular chemistry, 12(42), 8499-8504 (2014-09-19)
The aim of the present work is to develop two-channel emitters to probe local hydrophobicity by means of fluorescence quenching within different biomimetic supramolecular environments. To achieve this goal, the dansyl (Dns) and tryptophan (Trp) fluorophores have been covalently attached
Torao Suga et al.
Materials science & engineering. C, Materials for biological applications, 47, 345-350 (2014-12-11)
Hydrogels formed by low-molecular hydrogelators have been used as anti-microbial agents and cell-attachment materials. However the biomedical application of low-molecular gelators is slowly progressing compared to the hydrogels formed by polymer hydrogelator that is applied to biomedical application such as
Jae H Park et al.
Journal of medicinal chemistry, 57(15), 6623-6631 (2014-07-16)
The aqueous solution structure of protoxin II (ProTx II) indicated that the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region, similar to previously described NaSpTx III tarantula toxins. In the present study
Page 1 of 4