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Showing 1-30 of 78 results for "05-101" within Papers
Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles.
Priti S Hegde,David Rusnak,Melissa Bertiaux,Krystal Alligood,Jay Strum,Robert Gagnon,Tona M Gilmer
Molecular Cancer Therapeutics null
Changes in retinal cell fate induced by overexpression of EGF receptor
Lillien, L.
Nature, 377, 158-162 (1995)
Tomohiro Tanaka et al.
The Journal of biological chemistry, 293(7), 2288-2301 (2017-12-20)
The canonical description of transmembrane receptor function is initial binding of ligand, followed by initiation of intracellular signaling and then internalization en route to degradation or recycling to the cell surface. It is known that low concentrations of extracellular ligand
Takefumi Uemura et al.
Scientific reports, 8(1), 1368-1368 (2018-01-24)
Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ear-containing, ADP
Tomohiro Tanaka et al.
Oncology letters, 15(6), 9251-9256 (2018-05-29)
The aberrant activation of receptor tyrosine kinases (RTKs) is associated with tumor initiation in various types of human cancer, including non-small cell lung cancers (NSCLCs). Tyrosine kinase-independent non-canonical RTK regulation has also been investigated in tumor malignant alterations, including cellular
Yan Guan et al.
Science advances, 1(9), e1500633-e1500633 (2015-11-26)
Measuring small molecule interactions with membrane proteins in single cells is critical for understanding many cellular processes and for screening drugs. However, developing such a capability has been a difficult challenge. We show that molecular interactions with membrane proteins induce
Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.
Ling, BC; Wu, J; Miller, SJ; Monk, KR; Shamekh, R; Rizvi, TA; Decourten-Myers, G; Vogel et al.
Cancer Cell null
Gene transfection-mediated overexpression of beta1,4-N-acetylglucosamine bisecting oligosaccharides in glioma cell line U373 MG inhibits epidermal growth factor receptor function
Rebbaa, A., et al
The Journal of Biological Chemistry, 272, 9275-9279 (1997)
Yaping Zhang et al.
International journal of medical sciences, 19(5), 878-892 (2022-06-14)
Background: ECM proteins are instrumental for angiogenesis, which plays momentous roles during development and repair in various organs, including post cardiac insult. After a screening based on an open access RNA-seq database, we identified Nephronectin (NPNT), an extracellular protein, might
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
Greulich, H; Chen, TH; Feng, W; Janne, PA; Alvarez, JV; Zappaterra, M; Bulmer, SE; Frank et al.
PLoS Medicine null
M Jo et al.
The Journal of biological chemistry, 275(12), 8806-8811 (2000-03-18)
In rat liver epithelial cells constitutively expressing transforming growth factor alpha (TGFalpha), c-Met is constitutively phosphorylated in the absence of its ligand, hepatocyte growth factor. We proposed that TGFalpha and the autocrine activation of its receptor, epidermal growth factor receptor
J L Reiter et al.
Nucleic acids research, 24(20), 4050-4056 (1996-10-15)
The epidermal growth factor receptor (EGFR) is encoded by the c-erbB1 proto-oncogene and plays an important role in the control of cell growth and differentiation. To study the potential growth regulatory role of soluble EGF receptors, we have isolated cDNA
Amar Bennasroune et al.
Molecular biology of the cell, 15(7), 3464-3474 (2004-05-18)
Receptor tyrosine kinases have a single transmembrane (TM) segment that is usually assumed to play a passive role in ligand-induced dimerization and activation of the receptor. However, mutations within some of these receptors, and recent studies with the epidermal growth
Zhimin Feng et al.
Infection and immunity, 82(11), 4458-4465 (2014-08-13)
Currently, Acinetobacter baumannii is recognized as one of the major pathogens seriously threatening our health care delivery system. Aspects of the innate immune response to A. baumannii infection are not yet well understood. Human β-defensins (hBDs) are epithelial cell-derived cationic
Naohisa Oku et al.
Cancer research, 66(10), 5251-5257 (2006-05-19)
Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The
Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex.
Burrows, R C, et al.
Neuron, 19, 251-267 (1997)
Natsumi Kawasaki et al.
Cell discovery, 4, 1-1 (2018-02-10)
The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed
Adan Aguirre et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(48), 11092-11106 (2005-12-02)
Approaches to successful cell transplantation therapies for the injured brain involve selecting the appropriate neural progenitor type and optimizing the efficiency of the cell engraftment. Here we show that epidermal growth factor receptor (EGFR) expression enhances postnatal neural progenitor migration
Petia P Simeonova et al.
The Journal of biological chemistry, 277(4), 2945-2950 (2001-11-28)
Environmental or occupational exposure to arsenic is associated with a greatly increased risk of skin, urinary bladder, and respiratory tract cancers in arseniasis-endemic areas throughout the world. Arsenic shares many properties of tumor promoters by affecting specific cell signal transduction
Characterization of receptors of insect cytokine, growth-blocking peptide, in human keratinocyte and insect Sf9 cells.
Ohnishi, A; Oda, Y; Hayakawa, Y
The Journal of Biological Chemistry null
L Sauer et al.
Oncogene, 29(18), 2628-2637 (2010-03-02)
Early growth response-1 (Egr-1) is overexpressed in human prostate tumors and contributes to cancer progression. On the other hand, mutation of p53 is associated with advanced prostate cancer, as well as with metastasis and hormone independence. This study shows that
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells
Sexl, V., et al
The Journal of Biological Chemistry, 272, 5792-5799 (1997)
Polymorphonuclear leukocytes-mediated lysis of A431 cells induced by IgG1 mouse anti-epidermal growth factor receptor monoclonal antibodies.
Kawamoto, T, et al.
In Vitro Cellular & Developmental Biology, 28A, 782-786 (1992)
Susan C Kiley et al.
American journal of physiology. Renal physiology, 293(3), F895-F903 (2007-07-13)
In rodent models of obstructive nephropathy, exogenous epidermal growth factor (EGF) attenuates tubule cell death in rats and exacerbates cell death in mice. To identify species differences in EGF receptor (EGFR) regulation and signaling, cell lysates were prepared from rat
Robin Kuns et al.
Oncogene, 24(43), 6502-6515 (2005-07-12)
4.1B is a member of the protein 4.1 superfamily of proteins that link transmembrane proteins to the actin cytoskeleton. The 4.1B gene localizes to chromosome 18p11.3, which undergoes loss of heterozygosity in mammary tumors. Here, we examine the expression of
Autocrine regulation of DU145 human prostate cancer cell growth by epidermal growth factor-related polypeptides.
J M Connolly, D P Rose
Prostate null
Catarina Oliveira Silva et al.
PloS one, 11(10), e0165419-e0165419 (2016-10-28)
The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. The success of this application depends on the therapeutic efficiency and biocompatibility of the system, but also on the stability and biorecognition of the conjugated protein.
Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation.
Moghal, N and Neel, B G
Molecular and cellular biology, 18, 6666-6678 (1998)
Hitesh S Deshmukh et al.
American journal of respiratory cell and molecular biology, 38(4), 446-454 (2007-11-17)
Chronic obstructive pulmonary disease (COPD), a global public health problem, is characterized by progressive difficulty in breathing, with increased mucin production, especially in the small airways. Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increases
Catherine Le Quément et al.
American journal of physiology. Lung cellular and molecular physiology, 294(6), L1076-L1084 (2008-04-09)
Macrophage metalloelastase (MMP-12) is described to be involved in pulmonary inflammatory response. To determine the mechanisms linking MMP-12 and inflammation, we examined the effect of recombinant human MMP-12 (rhMMP-12) catalytic domain on IL-8/CXCL8 production in cultured human airway epithelial (A549)
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