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Showing 1-30 of 449 results for "05-389" within Papers
Florian Custodis et al.
Journal of vascular research, 49(5), 432-440 (2012-07-05)
Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein
Silvia Grasso et al.
Nature communications, 8, 14797-14797 (2017-03-17)
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast
Alice Truong et al.
The FEBS journal, 283(4), 704-722 (2015-12-15)
Membrane type 4 matrix metalloproteinase (MT4-MMP) [matrix metalloproteinase (MMP) 17] is a GPI-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple-negative breast cancer cells, MT4-MMP promotes primary tumour growth and lung metastases. Although the
Michela Brazzoli et al.
Journal of virology, 82(17), 8316-8329 (2008-06-27)
Infection with hepatitis C virus (HCV) is still a major public health problem, and the events leading to hepatocyte infection are not yet fully understood. Combining confocal microscopy with biochemical analysis and studies of infection requirements using pharmacological inhibitors and
Ger J A Ramakers et al.
Human molecular genetics, 21(2), 268-286 (2011-10-13)
Mutations in the ARHGEF6 gene, encoding the guanine nucleotide exchange factor αPIX/Cool-2 for the Rho GTPases Rac1 and Cdc42, cause X-linked intellectual disability (ID) in humans. We show here that αPix/Arhgef6 is primarily expressed in neuropil regions of the hippocampus.
Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration.
Gomathinayagam, R; Muralidharan, J; Ha, JH; Varadarajalu, L; Dhanasekaran, DN
Genes & Cancer null
Hung-Hsi Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(38), 9792-9804 (2016-09-23)
The RNA helicase DDX3 is a component of neuronal granules, and its gene mutations are linked to intellectual disability (ID). Here we demonstrate that DDX3 depletion in neurons impairs neurite development by downregulating Rac1 level and activation. Moreover, DDX3 activates
Robert G K Donald et al.
Microbiology (Reading, England), 159(Pt 7), 1254-1266 (2013-05-01)
The Clostridium difficile toxins A and B are primarily responsible for symptoms of C. difficile associated disease and are prime targets for vaccine development. We describe a plasmid-based system for the production of genetically modified toxins in a non-sporulating strain
Pontus Berglund et al.
Cancer research, 65(21), 9727-9734 (2005-11-04)
Cell cycle deregulation is a prerequisite in tumor development and overexpression of cyclin E, a major G1-S regulator, is often observed in breast cancer and is further linked to poor prognosis. By overexpressing cyclin E in a retinoblastoma-inactivated breast cancer
Henar Suárez et al.
Journal of extracellular vesicles, 10(7), e12082-e12082 (2021-05-21)
Tetraspanins are often used as Extracellular Vesicle (EV) detection markers because of their abundance on these secreted vesicles. However, data on their function on EV biogenesis are controversial and compensatory mechanisms often occur upon gene deletion. To overcome this handicap
Shigao Yang et al.
Science advances, 5(5), eaav7999-eaav7999 (2019-06-01)
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing self-destructive inflammation remains obscure. Here, we show that protein geranylgeranylation, a posttranslational lipid
Kent Sakai et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(11), 2590-2600 (2018-10-26)
Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this atheroprotection. We sought to determine the role of myeloid HMGCR
ZhenZhen Hu et al.
PloS one, 7(6), e38777-e38777 (2012-06-16)
Epidermal growth factor (EGF) signaling is implicated in the invasion and metastasis of hepatoma cells. However, the signaling pathways for EGF-induced motility of hepatoma cells remain undefined. We found that EGF dose-dependently stimulated the migration of human hepatoma cells HepG2
Oxana M Tsygankova et al.
Journal of cell science, 132(10) (2019-04-13)
Clathrin heavy chain is the structural component of the clathrin triskelion, but unique functions for the two distinct and highly conserved clathrin light chains (CLCa and CLCb, also known as CLTA and CLTB, respectively) have been elusive. Here, we show
Jayesh Deshmukh et al.
Oncotarget, 7(36), 57841-57850 (2016-08-11)
Overexpression and increased activity of the small Rho GTPase Rac1 has been linked to squamous cell carcinoma of the epidermis and mucosa in humans. Targeted deletion of Rac1 or inhibition of Rac1 activity in epidermal keratinocytes reduced papilloma formation in
Sachi Horibata et al.
BMC cancer, 17(1), 378-378 (2017-05-28)
Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarginine deiminase 2 (PAD2, aka PADI2) activity
Balint Csoboz et al.
Cell communication and signaling : CCS, 16(1), 51-51 (2018-08-31)
The outcome of cancer therapy is greatly defined by the ability of a tumor cell to evade treatment and re-establish its bulk mass after medical interventions. Consequently, there is an urgent need for the characterization of molecules affecting tumor reoccurrence.
Jiali Pu et al.
Experimental and therapeutic medicine, 14(3), 2277-2283 (2017-10-01)
It has been reported that FERM domain containing 7 (FRMD7) may cause X-linked idiopathic congenital nystagmus (ICN). A total of >40 mutations of the FRMD7 gene have been identified, however their pathogenic role remains unclear. In the present study, enhanced
Miriam Bothe et al.
Toxins, 7(2), 621-637 (2015-02-19)
The Gram-negative, intracellular bacterium Chlamydia trachomatis causes acute and chronic urogenital tract infection, potentially leading to infertility and ectopic pregnancy. The only partially characterized cytotoxin CT166 of serovar D exhibits a DXD motif, which is important for the enzymatic activity
Xiaolong Tang et al.
Cancer research, 73(20), 6206-6218 (2013-09-07)
Adhesion G-protein-coupled receptors (GPCR), which contain adhesion domains in their extracellular region, have been found to play important roles in cell adhesion, motility, embryonic development, and immune response. Because most adhesion molecules with adhesion domains have vital roles in cancer
Leo S Price et al.
The Journal of biological chemistry, 278(41), 39413-39421 (2003-07-31)
Rac is activated in response to various stimuli including growth factors and by adhesion to the extracellular matrix. However, how these stimuli ultimately result in Rac activation is poorly understood. The increase in intracellular calcium [Ca2+]i represents a ubiquitous second
Rashmi Priya et al.
Molecular biology of the cell, 28(1), 12-20 (2016-12-31)
Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in
Aneta Kwiatkowska et al.
Molecular cancer, 11, 65-65 (2012-09-13)
The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas. Previous work has identified roles for the Rho family guanine nucleotide exchange factors Trio and Vav3 in glioblastoma
Sónia Moniz et al.
Human molecular genetics, 22(1), 84-95 (2012-10-05)
The gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading
Murali K Akula et al.
Nature communications, 10(1), 3975-3975 (2019-09-06)
Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, leading to enhanced inflammatory responses and severe rheumatoid arthritis.
Magdalena H Menhofer et al.
Cardiovascular research, 104(2), 303-314 (2014-09-23)
Inhibiting angiogenesis is a major approach in tumour therapy. To combat angiogenesis, the tubulin cytoskeleton has emerged as an interesting target in many pre- and clinical studies. Contrarily, the actin cytoskeleton has been largely neglected as a potential drug target
Lushen Li et al.
Journal of cell science, 130(8), 1475-1485 (2017-03-08)
Surface expression of chemokine receptor CXCR4 is downregulated by missing-in-metastasis protein (MIM; also known as MTSS1), a member of the inverse BAR (I-BAR)-domain protein family that recognizes and generates membranes with negative curvature. Yet, the mechanism for the regulation is
Joëlle Deplazes et al.
Human molecular genetics, 18(19), 3632-3644 (2009-07-09)
Recent evidence suggests a close association between extracellular E-cadherin mutation in diffuse-type gastric carcinoma and the acquisition of a migratory phenotype of tumour cells. To characterize the cellular machinery that mediates the gain of motility of tumour cells with mutant
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
Ming, W; Li, S; Billadeau, DD; Quilliam, LA; Dinauer, MC
Molecular and cellular biology null
Enikö A Kramár et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(41), 12982-12993 (2009-10-16)
Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to synaptic operations. We report here that these acute actions are due to selective activation of an actin-signaling cascade normally used in the production of long-term
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