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Showing 1-30 of 31 results for "05-390" within Papers
Daniel J Zabransky et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(45), E6205-E6214 (2015-10-29)
Recurrent human epidermal growth factor receptor 2 (HER2) missense mutations have been reported in human cancers. These mutations occur primarily in the absence of HER2 gene amplification such that most HER2-mutant tumors are classified as "negative" by FISH or immunohistochemistry
Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer.
Deharvengt, S; Marmarelis, M; Korc, M
Testing null
T Fujioka et al.
European journal of biochemistry, 268(1), 25-34 (2000-12-20)
Short-term incubation of adult rat hepatocytes with epidermal growth factor (EGF) caused tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and IRS-2 when the cells had been submitted to primary culture from 1-18 h. Tyrosine-phosphorylated IRS-1 and IRS-2 bound to the
K M Darcy et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 48(1), 63-80 (2000-02-01)
Studies were undertaken to examine the natural role of ErbB2, ErbB3, and ErbB4 during the development of normal rat mammary epithelial cells (MECs) in vivo and in vitro. Immunohistochemical analysis demonstrated that mammary gland terminal end buds expressed abundant ErbB2
Frauke Muecksch et al.
Nature, 607(7917), 128-134 (2022-04-22)
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals1-3. Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious consequences of infection4. Here we examine the memory
Hideaki Dote et al.
Cancer research, 65(15), 6967-6975 (2005-08-03)
The ability to identify tumors that are susceptible to a given molecularly targeted radiosensitizer would be of clinical benefit. Towards this end, we have investigated the effects of a representative Hsp90 inhibitor, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG), on the radiosensitivity of a panel
Zhiguang Xiao et al.
Oncotarget, 5(24), 12877-12890 (2014-11-07)
The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After
Nikki L Sundholm-Peters et al.
Journal of neuropathology and experimental neurology, 64(12), 1089-1100 (2005-12-02)
Adult subventricular zone (SVZ) neuroblasts migrate in the rostral migratory stream to the olfactory bulbs. Brain lesions generally increase SVZ neurogenesis or gliogenesis and cause SVZ cell emigration to ectopic locations. We showed previously that glia emigrate from the SVZ
Christèle Desbois-Mouthon et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(17), 5445-5456 (2009-08-27)
The insulin-like growth factor (IGF) signaling axis is frequently dysregulated in hepatocellular carcinoma (HCC). Therefore, we investigated whether the specific targeting of the IGF type 1 receptor (IGF-1R) might represent a new therapeutic approach for this tumor. Total and phosphorylated
Yuxuan Wu et al.
Journal of cellular and molecular medicine, 20(3), 422-429 (2015-11-28)
The ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) is involved in the induction of apoptosis and suppression of tumour formation. We previously showed that it was expressed at lower levels in human glioma tissues compared with normal brain tissues.
Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.
Mahar, Ian, et al.
Testing, 6, e26610-e26610 (2011)
Vivian W Y Wong et al.
Nature cell biology, 14(4), 401-408 (2012-03-06)
Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling
Angela Lamarca et al.
PloS one, 13(10), e0206007-e0206007 (2018-10-20)
Expression of human epidermal growth factor receptor (HER)2 and HER3 have been investigated in small BTC studies using variable scoring systems. HER2 and HER3 overexpression/amplification were explored following internationally agreed guidelines using immunohistochemistry (IHC) and fluorescent in-situ hybridisation (FISH), respectively.
Martin Bezler et al.
Molecular oncology, 6(5), 516-529 (2012-07-31)
Resistance to chemotherapy is a serious problem for the successful treatment of ovarian cancer patients but signalling pathways that contribute to this chemoinsensitivity are largely unknown. We demonstrate that the chemotherapeutic drug doxorubicin induces activation of the HER3-PI3K-AKT signalling cascade
Björn Kruspig et al.
Science translational medicine, 10(446) (2018-06-22)
KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling; however
Molecular organization of the extraocular muscle neuromuscular junction: partial conservation of and divergence from the skeletal muscle prototype.
Sangeeta Khanna, Chelliah R Richmonds, Henry J Kaminski, John D Porter
Investigative Ophthalmology & Visual Science null
T Fujioka et al.
European journal of biochemistry, 268(15), 4158-4168 (2001-08-08)
In accordance with our recent results obtained with cultured rat hepatocytes [Fujioka, T. & Ui, M. (2001) Eur. J. Biochem. 268, 25-34], epidermal growth factor (EGF) gave rise to transient tyrosine phosphorylation of insulin receptor substrates (IRS-1 and IRS-2), thereby
Jia Xu et al.
Cancer discovery (2021-07-25)
Using a panel of cancer cell lines, we characterized a novel degrader of AKT, MS21. In mutant PI3K-PTEN pathway cell lines, AKT degradation was superior to AKT kinase inhibition for reducing cell growth and sustaining lower signaling over many days.
S J Keely et al.
The Journal of biological chemistry, 274(47), 33449-33454 (1999-11-24)
We have previously demonstrated that epidermal growth factor (EGF) inhibits calcium-dependent chloride secretion via a mechanism involving stimulation of phosphatidylinositol 3-kinase (PI3-K). The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the
Camille Fung et al.
Pediatric research, 72(1), 2-9 (2012-03-01)
Uteroplacental insufficiency (UPI) produces significant neurodevelopmental deficits affecting the hippocampus of intrauterine growth-restricted (IUGR) offspring. IUGR males have worse deficits as compared with IUGR females. The exact mechanisms underlying these deficits are unclear. Alterations in hippocampal cellular composition along with
Abdelhamid Beji et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(4), 956-968 (2011-12-07)
Abnormal accumulation and dysregulation of the epidermal growth factor receptor family member HER3 is associated with the development of various human cancers including those of the breast, lung, and ovary. We have previously shown that in melanoma HER3 is frequently
Victor A Levin et al.
Journal of proteome research, 9(1), 179-191 (2009-11-10)
Tumor cells undergoing serum starvation in vitro partially mimic metabolically stressed cells trying to adjust to a changed environment in vivo by inducing signal transduction and gene expression so that the tumor continues to grow. Our hypothesis is that the
Anna Ressa et al.
Molecular & cellular proteomics : MCP, 17(10), 1892-1908 (2018-07-05)
Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of cancer has resulted in more efficient strategies, where one or multiple drugs are adopted in novel therapies to
Zhiguang Xiao et al.
Oncotarget, 10(26), 2546-2560 (2019-05-10)
The lung cancer stem cell (LuCSC) model comprises an attractive framework to explore acquired drug resistance in non-small cell lung cancer (NSCLC) treatment. Here, we used NSCLC cell line model to translate cellular heterogeneity into tractable populations to understand the
P I Ezeh et al.
Journal of neurobiology, 37(2), 199-210 (1998-11-07)
Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor (EGF) are members of the EGF family of growth factors. They have a common receptor, the EGF receptor. This belongs to the tyrosine kinase group of receptors called the ErbB receptor family.
Robert Torka et al.
Neoplasia (New York, N.Y.), 16(4), 301-318 (2014-05-28)
The Axl receptor tyrosine kinase (RTK) has been established as a strong candidate for targeted therapy of cancer. However, the benefits of targeted therapies are limited due to acquired resistance and activation of alternative RTKs. Therefore, we asked if cancer
Conservation of synapse-signaling pathways at the extraocular muscle neuromuscular junction.
Sangeeta Khanna, John D Porter
Annals of the New York Academy of Sciences null
J C Trinidad et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(23), 8762-8770 (2000-01-11)
The neuregulin/erbB receptor and agrin/MuSK pathways are critical for communication between the nerve, muscle, and Schwann cell that establishes the precise topological arrangement at the vertebrate neuromuscular junction (NMJ). ErbB2, erbB3, and erbB4 as well as neuregulin, agrin, and MuSK
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity.
Scaltriti, M; Verma, C; Guzman, M; Jimenez, J; Parra, JL; Pedersen, K; Smith et al.
Oncogene null
D Fraccarollo et al.
Circulation, 96(11), 3963-3973 (1997-12-24)
Left ventricular dilatation after myocardial infarction is associated with impaired ventricular function and heart failure and has important implications for survival. The purpose of this study was to investigate the role of endothelin-1 (ET-1) in ventricular dilatation and the effects
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