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Showing 1-30 of 516 results for "05-724" within Papers
Tanja Kaufmann et al.
Nucleic acids research, 45(16), 9741-9759 (2017-09-22)
Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage sites in a PAR- and PCNA-dependent fashion. Here we
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells.
Fuping Zhang,Guangxun Meng,Warren Strober
Nature Immunology null
Donghui Kuang et al.
Journal of neurochemistry, 93(2), 383-391 (2005-04-09)
Members of the family C receptors within the G-protein coupled receptor superfamily include the metabotropic glutamate receptors, GABA(B) receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, the T1R taste receptors, and a small group of uncharacterized orphan receptors. We
Tanja Kaufmann et al.
Journal of cell science, 129(24), 4607-4621 (2016-11-23)
Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletion or overexpression causes nuclear
Clint M Upchurch et al.
Science advances, 8(28), eabn0050-eabn0050 (2022-07-21)
Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R--deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD). To examine the effect of OxPC elimination at different stages of NAFLD progression
Nef Suppresses LINE-1 Retrotransposition through Two Distinct Mechanisms.
Wang, et al.
Journal of virology, 96, e0114822-e0114822 (2022)
Anne Bernhardt et al.
The Plant journal : for cell and molecular biology, 47(4), 591-603 (2006-06-24)
Cullins are central scaffolding subunits in eukaryotic E3 ligases that facilitate the ubiquitination of target proteins. Arabidopsis contains at least 11 cullin proteins but only a few of them have been assigned biological roles. In this work Arabidopsis cullin 4
Jin-Woo Lee et al.
Journal of hematology & oncology, 14(1), 148-148 (2021-09-18)
Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance. Herein, we found Kai1 knockout mice showed significantly enhanced
Franziska Uhlenbrock et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1654-1665 (2014-07-16)
Soluble ULBP2 is a marker for poor prognosis in several types of cancer. In this study we demonstrate that both soluble and cell surface-bound ULBP2 is transported via a so far unrecognized endosomal pathway. ULBP2 surface expression, but not MICA/B
David Tandio et al.
Scientific reports, 9(1), 13555-13555 (2019-09-21)
Adenosine has been reported to be transported by equilibrative nucleoside transporter 4 (ENT4), encoded by the SLC29A4 gene, in an acidic pH-dependent manner. This makes hENT4 of interest as a therapeutic target in acidic pathologies where adenosine is protective (e.g.
Bart J H Dequeker et al.
Nature, 606(7912), 197-203 (2022-05-19)
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)1-3, which contribute to transcription, recombination and genomic stability4,5. Cohesin extrudes DNA into loops that are thought to lengthen until CTCF boundaries are encountered6-12. Little is known about whether loop
Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis.
Liu, Y; Li, X; Li, K; Liu, H; Lin, C
PLoS Genetics null
Renée C G de Bruin et al.
Oncoimmunology, 7(1), e1375641-e1375641 (2018-01-04)
Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and are therefore of major interest to explore for cancer immunotherapy. Vγ9Vδ2-T cell-based cancer
Michael Whaby et al.
The Journal of biological chemistry, 298(12), 102661-102661 (2022-11-06)
Mutations in one of the three RAS genes (HRAS, KRAS, and NRAS) are present in nearly 20% of all human cancers. These mutations shift RAS to the GTP-loaded active state due to impairment in the intrinsic GTPase activity and disruption
Nicholas Doerr et al.
PloS one, 11(8), e0161525-e0161525 (2016-08-26)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. The PC1/PC2
Xiangzhi Li et al.
Molecular and cellular biology, 31(2), 351-364 (2010-11-10)
The Polycomb group of proteins forms at least two distinct complexes designated the Polycomb repressive complex-1 (PRC1) and PRC2. These complexes cooperate to mediate transcriptional repression of their target genes, including the Hox gene cluster and the Cdkn2a genes. Mammalian
Christoph Neumayr et al.
Nature, 606(7913), 406-413 (2022-06-02)
All multicellular organisms rely on differential gene transcription regulated by genomic enhancers, which function through cofactors that are recruited by transcription factors1,2. Emerging evidence suggests that not all cofactors are required at all enhancers3-5, yet whether these observations reflect more
Michela Rossini et al.
Cells, 10(8) (2021-08-28)
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer's disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide formation. In
Nobuyuki Takenaka et al.
The Biochemical journal, 469(3), 445-454 (2015-07-25)
Insulin-stimulated glucose uptake in skeletal muscle is mediated by the translocation of the glucose transporter GLUT4 from intracellular storage sites to the plasma membrane. The small GTPase Rac1 has been implicated in this insulin signalling, but the mechanism whereby Rac1
Christopher J Kershaw et al.
RNA biology, 1-19 (2021-10-22)
Non-membrane-bound compartments such as P-bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically and quantitatively determined the protein and mRNA composition of PBs and SGs formed before and
Sota Kuno et al.
The Journal of biological chemistry, 299(5), 104701-104701 (2023-04-15)
To ensure proper utilization of iron and avoid its toxicity, cells are equipped with iron-sensing proteins to maintain cellular iron homeostasis. We showed previously that nuclear receptor coactivator 4 (NCOA4), a ferritin-specific autophagy adapter, intricately regulates the fate of ferritin;
Mihoko Kajita et al.
Nature communications, 5, 4428-4428 (2014-08-01)
Recent studies have shown that certain types of transformed cells are extruded from an epithelial monolayer. However, it is not known whether and how neighbouring normal cells play an active role in this process. In this study, we demonstrate that
Fredj ben Bdira et al.
Human molecular genetics, 23(21), 5805-5813 (2014-06-14)
Congenital erythropoietic porphyria (CEP) results from a deficiency in uroporphyrinogen III synthase enzyme (UROIIIS) activity that ultimately stems from deleterious mutations in the uroS gene. C73 is a hotspot for these mutations and a C73R substitution, which drastically reduces the
Sebastian Koob et al.
Biochimica et biophysica acta, 1853(7), 1551-1563 (2015-03-15)
Mitochondrial membrane architecture is important for organelle function. Alterations thereof are linked to a number of human disorders including diabetes and cardiomyopathy. The MICOS complex was recently reported to be a central player determining cristae structure and formation of crista
Naomi Li et al.
Nucleic acids research, 44(18), 8726-8741 (2016-07-02)
Sam68 is a known sequence-specific RNA binding protein that regulates alternative splicing events during the cell cycle and apoptosis. Sam68 has also been shown to influence transcription, but the molecular mechanism remains undefined. Herein we identify Sam68 as a transcriptional
Rikke Illum Høgh et al.
Journal of immunology (Baltimore, Md. : 1950), 204(7), 1746-1759 (2020-03-08)
Fumarate is a tricarboxylic acid cycle metabolite whose intracellular accumulation is linked to inflammatory signaling and development of cancer. In this study, we demonstrate that endogenous fumarate accumulation upregulates surface expression of the immune stimulatory NK group 2, member D
Meng Wang et al.
Retrovirology, 15(1), 65-65 (2018-09-23)
Human immunodeficiency virus type 1 (HIV-1) Tat protein plays an essential role in HIV-1 gene transcription. Tat transactivates HIV-1 long terminal repeat (LTR)-directed gene expression through direct interactions with the transactivation-responsive region (TAR) element and other cis elements in the
Sonja Dittmer et al.
Journal of cell science, 124(Pt 2), 252-260 (2010-12-22)
TOX3 is a nuclear protein containing a high mobility group (HMG)-box domain, which regulates Ca(2+)-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and was previously shown to be
SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.
Lee, et al.
Experimental & Molecular Medicine (2023)
Wolfgang Paster et al.
Journal of immunology (Baltimore, Md. : 1950), 190(7), 3749-3756 (2013-03-06)
Thymocyte-expressed molecule involved in selection (THEMIS) is a recently identified regulator of thymocyte positive selection. THEMIS's mechanism of action is unknown, and whether it has a role in TCR-proximal signaling is controversial. In this article, we show that THEMIS and
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