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Showing 1-19 of 19 results for "05-915" within Papers
Dawn R Cochrane et al.
Hormones & cancer, 1(6), 306-319 (2011-07-16)
To identify microRNAs (miRNAs) associated with estrogen receptor (ESR1) status, we profiled luminal A, ESR1+ breast cancer cell lines versus triple negative (TN), which lack ERα, progesterone receptor and Her2/neu. Although two thirds of the differentially expressed miRNAs are higher
Shigetomi Tanaka et al.
International journal of cancer, 131(11), 2537-2546 (2012-04-11)
Loss or decreased expression of runt-related transcription factor 3 (RUNX3), a tumor suppressor gene involved in gastric and other cancers, has been frequently observed in hepatocellular carcinoma (HCC). The objective of this study was to identify the regulatory mechanism of
Stéphane Chabaud et al.
Oncology letters, 24(1), 220-220 (2022-06-21)
During the process of tumor growth, cancer cells will be subjected to intermittent hypoxia. This results from the delay in the development of the vascular network in relation to the proliferation of cancer cells. The hypoxic nature of a tumor
The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.
Gooding, Jane M, et al.
Bioessays, 26, 497-511 (2004)
Shanmugarajan Krishnan et al.
Oncotarget, 6(26), 22480-22495 (2015-06-20)
Glioblastoma are among the most angiogenic tumors. The molecular mechanisms that control blood vessel formation by endothelial cells (EC) in glioblastoma remain incompletely understood. Transforming growth factor-β (TGF-β) is a key regulatory cytokine that has proinvasive and stemness-maintaining autocrine properties
Tsutomu Nakamura et al.
Genes & development, 22(9), 1244-1256 (2008-05-03)
Cadherins mediate Ca2+-dependent cell-cell adhesion. Efficient export of cadherins from the endoplasmic reticulum (ER) is known to require complex formation with beta-catenin. However, the molecular mechanisms underlying this requirement remain elusive. Here we show that PX-RICS, a beta-catenin-interacting GTPase-activating protein
Yadi Wu et al.
Nature communications, 8, 14228-14228 (2017-02-16)
Snail1, a key transcription factor of epithelial-mesenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours remains unclear. We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and
Abdul Soofi et al.
Developmental biology, 365(1), 241-250 (2012-03-14)
The Pax2 gene encodes a DNA binding protein with multiple functions in the developing intermediate mesoderm and urogenital tract. Loss of Pax2 in mice results in the complete absence of kidneys, ureters, and sex specific epithelial structures derived from the
Epstein-Barr virus-induced epigenetic alterations following transient infection.
Queen, KJ; Shi, M; Zhang, F; Cvek, U; Scott, RS
International Journal of Cancer. Journal International Du Cancer null
Lei Wang et al.
Oncology reports, 42(5), 2169-2178 (2019-08-23)
Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of <20%. Early malignant cell dissemination contributes to this poor prognosis. Epithelial‑mesenchymal transition (EMT) induces the invasion and metastasis of carcinoma cells. Empty
X-J Fan et al.
British journal of cancer, 106(11), 1735-1741 (2012-04-28)
Current imaging modalities are inadequate in preoperatively predicting regional lymph node metastasis (RLNM) status in rectal cancer (RC). Here, we designed support vector machine (SVM) model to address this issue by integrating epithelial-mesenchymal-transition (EMT)-related biomarkers along with clinicopathological variables. Using
Dawn R Cochrane et al.
Molecular cancer therapeutics, 8(5), 1055-1066 (2009-05-14)
The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal transition due to its ability to repress E-cadherin and other genes involved in polarity. Recently, ZEB1 and ZEB2 have
Laura Mosca et al.
International journal of oncology, 56(5), 1212-1224 (2020-04-23)
S‑Adenosyl‑L‑methionine (AdoMet) is the principal methyl donor in transmethylation reactions fundamental to sustaining epigenetic modifications. Over the past decade, AdoMet has been extensively investigated for its anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in several types of human cancer. Head and neck
Dapeng Sun et al.
PloS one, 17(9), e0274919-e0274919 (2022-09-23)
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR
Chih-Hung Hsu et al.
The EMBO journal, 23(11), 2269-2280 (2004-05-14)
Targeting of cellular histone acetyltransferases (HATs) by viral proteins is important in the development of virus-associated diseases. The immediate-early 2 protein (IE2) of human cytomegalovirus (HCMV) binds to the tumor suppressor, p53, and inactivates its functions by unknown mechanisms. Here
Zhaoping Qiu et al.
Theranostics, 11(16), 7658-7670 (2021-08-03)
SNAI1 is widely regarded as a master driver of epithelial-mesenchymal transition (EMT) and associated with breast cancer progression and metastasis. This pro-malignant role is strongly linked to posttranslational modification, especially phosphorylation, which controls its protein levels and subcellular localization. While
Structure-based models of cadherin-mediated cell adhesion: the evolution continues.
Koch, A W, et al.
Cellular and Molecular Life Sciences, 61, 1884-1895 (2004)
Alexander Schneider et al.
Alcohol (Fayetteville, N.Y.), 32(1), 19-24 (2004-04-07)
The pathophysiologic mechanisms underlying alcoholic chronic pancreatitis are poorly understood. Cytokines participate in the immunologic progression of acute and chronic pancreatitis and may play an important role in the development of pancreatic fibrosis. Functional polymorphisms in cytokine genes have been
Lonnie T Sullivan et al.
American heart journal, 214, 46-53 (2019-06-04)
Some studies suggest that black patients may have worse outcomes after drug-eluting stent (DES) placement. There are limited data characterizing long-term outcomes by race. The objective was to compare long-term outcomes between black and white patients after percutaneous coronary intervention
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