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Showing 1-25 of 25 results for "06-315" within Papers
D Leo et al.
Genes, brain, and behavior, 8(3), 356-368 (2009-02-27)
Methylphenidate (MPH) administration to adolescent rodents produces persistent region-specific changes in brain reward circuits and alterations of reward-based behavior. We show that these modifications include a marked increment of serotonin (5-hydroxy-tryptamine) receptor type 7 (Htr7) expression and synaptic contacts, mainly
Changcheng Sun et al.
The Journal of biological chemistry, 288(34), 24676-24690 (2013-07-19)
Kainate receptors (KARs) are one of the ionotropic glutamate receptors that mediate excitatory postsynaptic currents (EPSCs) with characteristically slow kinetics. Although mechanisms for the slow kinetics of KAR-EPSCs are not totally understood, recent evidence has implicated a regulatory role of
J H Brandstätter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(23), 9298-9307 (1997-12-31)
The synaptic localization of the kainate receptor subunits GluR6/7 and KA2 and of the ionotropic glutamate receptor subunits delta1/2 was studied in the rat retina using receptor-specific antisera. GluR6/7 and KA2 were present in both synaptic layers of the retina:
Françoise Coussen et al.
Neuron, 47(4), 555-566 (2005-08-17)
Kainate receptors (KAR) are composed of several distinct subunits and splice variants, but the functional relevance of this diversity remains largely unclear. Here we show that two splice variants of the GluR6 subunit, GluR6a and GluR6b, which differ in their
Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury.
Hai-Xia Jiang, Qiu-Hua Guan, Dong-Sheng Pei, Guang-Yi Zhang
Journal of Neuroscience Research null
S Mehta et al.
The Journal of biological chemistry, 276(19), 16092-16099 (2001-03-30)
Recent studies have demonstrated that kainate receptors are associated with members of the SAP90/PSD-95 family (synapse-associated proteins (SAPs)) in neurons and that SAP90 can cluster and modify the electrophysiological properties of GluR6/KA2 kainate receptors when co-expressed in transfected cells. In
Seil Jang et al.
Frontiers in synaptic neuroscience, 12, 567075-567075 (2021-01-08)
Synaptic adhesion molecules regulate synapse development through trans-synaptic adhesion and assembly of diverse synaptic proteins. Many synaptic adhesion molecules positively regulate synapse development; some, however, exert negative regulation, although such cases are relatively rare. In addition, synaptic adhesion molecules regulate
Pornpun Vivithanaporn et al.
The Journal of biological chemistry, 281(22), 15475-15484 (2006-04-06)
Assembly and trafficking of neurotransmitter receptors are processes contingent upon interactions between intracellular chaperone systems and discrete determinants in the receptor proteins. Kainate receptor subunits, which form ionotropic glutamate receptors with diverse roles in the central nervous system, contain a
Sanja Selak et al.
Neuron, 63(3), 357-371 (2009-08-15)
Regulation of surface insertion and internalization of AMPA and NMDA receptors has emerged as a key mechanism for the control of synaptic strength. Regulatory elements for synaptic kainate receptors (KARs) are, however, largely undetermined. We have found that SNAP25 is
Xiaoling Li et al.
Channels (Austin, Tex.), 11(6), 616-623 (2017-08-25)
Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have been shown to regulate KAR surface expression, trafficking and synaptic plasticity. In addition, our previous study has shown that a phosphorylation-dependent interaction of 14-3-3τ and GluK2a-containing receptors contributes to
E P Garcia et al.
Neuron, 21(4), 727-739 (1998-11-10)
The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with
Arnaud Ruiz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(50), 11710-11718 (2005-12-16)
Heteromeric kainate receptors (KARs) containing both glutamate receptor 6 (GluR6) and KA2 subunits are involved in KAR-mediated EPSCs at mossy fiber synapses in CA3 pyramidal cells. We report that endogenous glutamate, by activating KARs, reversibly inhibits the slow Ca2+-activated K+
Synaptic expression of the high-affinity kainate receptor subunit KA2 in hippocampal cultures
Roche, K. W. and Huganir, R. L.
Neuroscience, 69, 383-393 (1995)
Izumi Iida et al.
Scientific reports, 14(1), 4521-4521 (2024-02-25)
Kainate receptors (KARs) are one of the ionotropic glutamate receptors in the central nervous system (CNS) comprised of five subunits, GluK1-GluK5. There is a growing interest in the association between KARs and psychiatric disorders, and there have been several studies
Scott E Hemby et al.
Journal of neurochemistry, 95(6), 1785-1793 (2005-12-21)
Chronic cocaine and withdrawal induce significant alterations in nucleus accumbens (NAc) glutamatergic function in humans and rodent models of cocaine addiction. Dysregulation of glutamatergic function of the prefrontal cortical-NAc pathway has been proposed as a critical substrate for unmanageable drug
Yu-Show Fu et al.
Journal of biomedical science, 11(5), 652-660 (2004-08-19)
Neuronal transplantation has provided a promising approach for treating neurodegenerative diseases. Recently, efforts have been directed at in vitro induction of various stem cells to transform into neurons. We report the first successful quantities in an in vitro attempt at
Gary P Brennan et al.
PloS one, 8(1), e54491-e54491 (2013-01-30)
14-3-3 proteins are ubiquitous molecular chaperones that are abundantly expressed in the brain where they regulate cell functions including metabolism, the cell cycle and apoptosis. Brain levels of several 14-3-3 isoforms are altered in diseases of the nervous system, including
A Herb et al.
Neuron, 8(4), 775-785 (1992-04-01)
A new ionotropic glutamate receptor subunit termed KA-2, cloned from rat brain cDNA, exhibits high affinity for [3H]kainate (KD approximately 15 nM). KA-2 mRNA is widely expressed in embryonic and adult brain. Homomeric KA-2 expression does not generate agonist-sensitive channels
Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
Agrawal, S. K. and Fehlings, M. G.
The Journal of Neuroscience, 17, 1055-1063 (1997)
Sho Wakayama et al.
Nature communications, 8, 14850-14850 (2017-04-08)
The location and number of neurotransmitter receptors are dynamically regulated at postsynaptic sites. However, currently available methods for visualizing receptor trafficking require the introduction of genetically engineered receptors into neurons, which can disrupt the normal functioning and processing of the
Françoise Coussen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(15), 6426-6436 (2002-08-02)
Kainate receptors modulate synaptic transmission by acting either at presynaptic or at postsynaptic sites. The precise localization of kainate receptors as well as the mechanisms of targeting and stabilization of these receptors in neurons are largely unknown. We have generated
Margaret M Madeleine et al.
The Journal of infectious diseases, 186(11), 1565-1574 (2002-11-26)
The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II DRB1 and DQB1 genes were examined
Yuan Zhang et al.
PloS one, 7(6), e39247-e39247 (2012-06-23)
The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors. To replicate and extend our recent findings from genetic association studies in chronic rhinosinusitis (CRS) performed
Katharina Mederle et al.
American journal of physiology. Renal physiology, 304(9), F1198-F1209 (2013-02-22)
WNK3 kinase is expressed throughout the nephron and acts as a positive regulator of NKCC2 and NCC in vitro. Here we addressed the in vivo relevance of WNK3 using WNK3-deficient mice. WNK3-/- mice were viable and showed no gross abnormalities.
J D Cowan et al.
Journal of the National Cancer Institute, 83(15), 1077-1084 (1991-08-17)
Four hundred eleven women with metastatic breast cancer were randomly assigned to receive either 60 mg/m2 doxorubicin (130 patients), 320 mg/m2 bisantrene (146 patients), or 14 mg/m2 mitoxantrone (135 patients). The doses were given intravenously every 3 weeks with a
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