06-807

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Showing 1-30 of 48 results for "06-807" within Papers

Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor.

Alexandre K Rouquette-Jazdanian et al.

The Biochemical journal, 363(Pt 3), 645-655 (2002-04-20)

Cell membranes contain sphingolipids and cholesterol, which cluster together in distinct domains called rafts. The outer-membrane leaflet of these peculiar membrane domains contains glycosylphosphatidylinositol-anchored proteins, while the inner leaflet contains proteins implicated in signalling, such as the acylated protein kinase

AT9283, 1-Cyclopropyl-3-(3-(5-(Morpholinomethyl)-1H-Benzo[d]Imidazole-2-yl)-1H-Pyrazol-4-yl) Urea, Inhibits Syk to Suppress Mast Cell-Mediated Allergic Response.

Su Jeong Kim et al.

Biomolecules & therapeutics, 30(6), 520-528 (2022-10-29)

Mast cells are an effector cell that plays a pivotal role in type I hypersensitive immune responses. Mast cells exist in connective tissues, such as skin and mucosal tissue, and contain granules which contain bioactive substances such as histamine and

Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways.

Gringhuis, SI; Papendrecht-van der Voort, EA; Leow, A; Nivine Levarht, EW; Breedveld et al.

Molecular and cellular biology null

Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.

Hun Sik Kim et al.

Science signaling, 5(232), ra49-ra49 (2012-07-13)

The cytotoxic effects of natural killer (NK) cells and their ability to secrete cytokines require synergistic signals from specific pairs of co-activation receptors, such as CD314 (also known as NKG2D) and CD244 (2B4), which bind to distinct ligands present on

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1.

Seeyoung Choi et al.

The Journal of experimental medicine, 220(7) (2023-04-18)

The T-lineage restricted protein THEMIS has been shown to play a critical role in T cell development. THEMIS, via its distinctive CABIT domains, inhibits the catalytic activity of the tyrosine phosphatase SHP1 (PTPN6). SHP1 and THEMIS bind to the ubiquitous

Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.

Jean-Marie Carpier et al.

The Journal of experimental medicine, 215(4), 1245-1265 (2018-02-15)

The adapter molecule linker for activation of T cells (LAT) orchestrates the formation of signalosomes upon T cell receptor (TCR) stimulation. LAT is present in different intracellular pools and is dynamically recruited to the immune synapse upon stimulation. However, the

Identification of functional, short-lived isoform of linker for activation of T cells (LAT).

M Kłossowicz et al.

Genes and immunity, 15(7), 449-456 (2014-07-11)

Linker for activation of T cells (LAT) is a transmembrane adaptor protein playing a key role in the development, activation and maintenance of peripheral homeostasis of T cells. In this study we identified a functional isoform of LAT. It originates

T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.

Teixeiro, Emma, et al.

The Journal of Biological Chemistry, 277, 3993-4002 (2002)

Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.

S I Gringhuis, A Leow, E A Papendrecht-Van Der Voort, P H Remans, F C Breedveld, C L Verweij

Journal of immunology (Baltimore, Md. : 1950) (1950)

Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.

K Marek-Bukowiec et al.

Genes and immunity, 17(5), 313-320 (2016-06-10)

Linker for activation of T cells (LAT) is a raft-associated, transmembrane adapter protein critical for T-cell development and function. LAT expression is transiently upregulated upon T-cell receptor (TCR) engagement, but molecular mechanisms conveying TCR signaling to enhanced LAT transcription are

Phospholipase C?2 plays a role in TCR signal transduction and T cell selection.

Fu, G; Chen, Y; Schuman, J; Wang, D; Wen, R

Journal of immunology (Baltimore, Md. : 1950) (1950)

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

W Zhang et al.

Cell, 92(1), 83-92 (1998-03-07)

Despite extensive study, several of the major components involved in T cell receptor-mediated signaling remain unidentified. Here we report the cloning of the cDNA for a highly tyrosine-phosphorylated 36-38 kDa protein, previously characterized by its association with Grb2, phospholipase C-gamma1

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation.

Gregory Driessens et al.

Journal of immunology (Baltimore, Md. : 1950), 186(2), 784-790 (2010-12-15)

Despite the defined function of the β-catenin pathway in thymocytes, its functional role in peripheral T cells is poorly understood. We report that in a mouse model, β-catenin protein is constitutively degraded in peripheral T cells. Introduction of stabilized β-catenin

Endogenous phospholipase D2 localizes to the plasma membrane of RBL-2H3 mast cells and can be distinguished from ADP ribosylation factor-stimulated phospholipase D1 activity by its specific sensitivity to oleic acid.

Elisabeth Sarri et al.

The Biochemical journal, 369(Pt 2), 319-329 (2002-10-11)

We have examined the specificity of oleate as an activator of phospholipase D2 (PLD2) and whether it can be used to study PLD2 localization and its involvement in cell function. Oleate stimulates PLD activity in intact RBL-2H3 mast cells. Comparing

Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level.

Klossowicz, Mikolaj, et al.

Journal of Immunological Methods, 389, 9-17 (2013)

The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function.

Marc-Werner Dobenecker et al.

Molecular and cellular biology, 25(23), 10533-10542 (2005-11-17)

Regulation of Src family kinase (SFK) activity is indispensable for a functional immune system and embryogenesis. The activity of SFKs is inhibited by the presence of the carboxy-terminal Src kinase (Csk) at the cell membrane. Thus, recruitment of cytosolic Csk

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism.

Juan José Saez et al.

Cells, 10(2) (2021-02-13)

LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments. Upon T cell activation the intracellular pool of LAT

Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses.

Trond Methi et al.

Journal of immunology (Baltimore, Md. : 1950), 175(11), 7398-7406 (2005-11-23)

The Src family kinase Lck is essential for T cell Ag receptor-mediated signaling. In this study, we report the effects of acute elimination of Lck in Jurkat TAg and primary T cells using RNA interference mediated by short-interfering RNAs. In

The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway.

Jacob Ngai et al.

European journal of immunology, 38(11), 3208-3218 (2008-11-11)

Here, we examined the functional involvement of heterotrimeric G-proteins in TCR-induced immune responses. TCR/CD3 crosslinking resulted in activation of both Galphaq and Galphas, but not Galphai-2. Targeting of Galphas, Galphai-2 and Galphaq using siRNA demonstrated a specific role of Galphaq

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Monika Raab et al.

Nature communications, 8, 16001-16001 (2017-07-13)

Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.

Guillaume Gaud et al.

Science signaling, 11(538) (2018-07-12)

The activation of T cells requires the guanine nucleotide exchange factor VAV1. Using mice in which a tag for affinity purification was attached to endogenous VAV1 molecules, we analyzed by quantitative mass spectrometry the signaling complex that assembles around activated

T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering.

Hashimoto-Tane, A; Yokosuka, T; Ishihara, C; Sakuma, M; Kobayashi, W; Saito, T

Molecular and cellular biology null

Vitamin D controls T cell antigen receptor signaling and activation of human T cells.

von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C

Nature Immunology null

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

Wange, R L, et al.

The Journal of Biological Chemistry, 270, 18730-18733 (1995)

Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies.

T Harder et al.

The Journal of cell biology, 151(2), 199-208 (2000-10-19)

Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of

The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.

Daisuke Aki et al.

Nature immunology, 19(7), 766-775 (2018-06-22)

The mechanisms by which the sensitivity of naive CD4+ T cells to stimulation by the cognate antigen via the T cell antigen receptor (TCR) determines their differentiation into distinct helper T cell subsets remain elusive. Here we demonstrate functional collaboration

Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

Misra, RS; Russell, JQ; Koenig, A; Hinshaw-Makepeace, JA; Wen, R; Wang, D; Huo et al.

The Journal of Biological Chemistry null

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets.

Ilaria Canobbio et al.

Cellular signalling, 20(9), 1662-1670 (2008-06-28)

Rap1b and Rap2b are the only members of the Rap family of GTPases expressed in circulating human platelets. Rap1b is involved in the inside-out activation of integrins, while the role of Rap2b is still poorly understood. In this work, we

OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.

Takanori So et al.

Journal of immunology (Baltimore, Md. : 1950), 186(6), 3547-3555 (2011-02-04)

T lymphocyte activation requires signal 1 from the TCR and signal 2 from costimulatory receptors. For long-lasting immunity, growth and survival signals imparted through the Akt/protein kinase B (PKB) pathway in activated or effector T cells are important, and these

Persistence of cooperatively stabilized signaling clusters drives T-cell activation.

Bunnell, SC; Singer, AL; Hong, DI; Jacque, BH; Jordan, MS; Seminario, MC; Barr et al.

Molecular and cellular biology null

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