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07-356
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Showing 1-30 of 30 results for "07-356" within Papers
NR3 protein expression in trigeminal neurons during postnatal development.
Brain Research null
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(39), 8262-8277 (2021-08-21)
Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from cocaine self-administration in rats and humans. In rats, the expression of incubation ultimately depends on Ca2+-permeable AMPARs that accumulate in synapses onto medium spiny neurons (MSNs) in the NAc core. However
The Journal of biological chemistry, 295(25), 8613-8627 (2020-05-13)
N-Methyl-d-aspartate type glutamate receptors (NMDARs) are key mediators of synaptic activity-regulated gene transcription in neurons, both during development and in the adult brain. Developmental differences in the glutamate receptor ionotropic NMDA 2 (GluN2) subunit composition of NMDARs determines whether they
Scientific reports, 9(1), 9486-9486 (2019-07-03)
Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPAR) to the postsynaptic membrane. PSD-95 disruption has recently been associated with neuropsychiatric disorders
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(35), 10961-10973 (2009-09-04)
Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-beta (Abeta) can suppress synaptic activities by interacting with alpha7 nicotinic acetylcholine receptors (alpha7nAChRs). Here, we show that alpha7nAChR and NMDA
Journal of neurochemistry, 143(3), 320-333 (2017-06-20)
Schizophrenia (SCZ) is characterized not only by psychosis, but also by working memory and executive functioning deficiencies, processes that rely on the prefrontal cortex (PFC). Because these cognitive impairments emerge prior to psychosis onset, we investigated synaptic function during development
Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration.
Brain Research null
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(3), 575-585 (2017-12-03)
Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine. This increase in GluA1 may be dependent on concomitant NMDA receptor (NMDAR) activation during self-administration, similar to cocaine-induced long-term
N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.
American Journal of Physiology: Renal Physiology null
Structure and function of glutamate receptor ion channels.
Annual Review of Physiology, 66, 161-181 (2004)
Genetic deletion of NR3A accelerates glutamatergic synapse maturation.
Testing null
Journal of neurochemistry, 137(2), 164-176 (2016-01-31)
Neuronal activity sculpts brain development by inducing the transcription of genes such as brain-derived neurotrophic factor (Bdnf) that modulate the function of synapses. Sensory experience is transduced into changes in gene transcription via the activation of calcium signaling pathways downstream
Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.
Cerebral Cortex (1991)
eLife, 10 (2021-11-18)
De novo protein synthesis is required for synapse modifications underlying stable memory encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be regulated at the synapse level is unknown. Here, we characterize neuronal signaling complexes formed by
Prenatal development of NMDA receptor composition and function in trigeminal neurons.
Archives of Histology and Cytology null
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9213-9221 (2014-07-11)
Synaptic rearrangements during critical periods of postnatal brain development rely on the correct formation, strengthening, and elimination of synapses and associated dendritic spines to form functional networks. The correct balance of these processes is thought to be regulated by synapse-specific
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(8), 1778-1787 (2020-01-19)
Increase in blood-brain barrier (BBB) permeability is a crucial step in neuroinflammatory processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed on cerebral endothelial cells forming the BBB, regulate immune cell infiltration across this barrier in the
Methods in molecular biology (Clifton, N.J.), 1677, 253-263 (2017-10-08)
Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The
Cell reports, 42(5), 112477-112477 (2023-05-07)
Signaling via N-methyl-d-aspartate receptors (NMDARs) is critical for the maturation of glutamatergic synapses, partly through a developmental switch from immature synapses expressing primarily GluN2B- and GluN3A-containing subtypes to GluN2A-rich mature ones. This subunit switch is thought to underlie the synaptic
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
Life Sciences, 74, 329-336 (2003)
Amino terminal domain regulation of NMDA receptor function.
European Journal of Pharmacology, 500, 101-111 (2004)
Region specific regulation of NR1 in rhesus monkeys following chronic antipsychotic drug administration.
Biological Psychiatry null
Nature, 415(6873), 793-798 (2002-02-02)
The N-methyl-D-aspartate subtype of glutamate receptor (NMDAR) serves critical functions in physiological and pathological processes in the central nervous system, including neuronal development, plasticity and neurodegeneration. Conventional heteromeric NMDARs composed of NR1 and NR2A-D subunits require dual agonists, glutamate and
Frontiers in cellular neuroscience, 12, 16-16 (2018-02-17)
Glycogen synthase kinase 3β (GSK3β) is a highly conserved serine/threonine kinase that has been implicated in both psychiatric and neurodegenerative diseases including schizophrenia, bipolar disorder, and Alzheimer's disease; therefore regulating its activity has become an important strategy for treatment of
Nature, 393(6683), 377-381 (1998-06-10)
The NMDA (N-methyl-D-aspartate) subclass of glutamate receptor is essential for the synaptic plasticity thought to underlie learning and memory and for synaptic refinement during development. It is currently believed that the NMDA receptor (NMDAR) is a heteromultimeric channel comprising the
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(2), 328-340 (2012-09-13)
The N-methyl-D-aspartate (NMDA) receptor has long been associated with learning and memory processes as well as diseased states, particularly in schizophrenia (SZ). Additionally, SZ is increasingly recognized as a neurodevelopmental disorder with cognitive impairments often preceding the onset of psychosis.
PLoS biology, 16(12), e2006838-e2006838 (2018-12-27)
The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental
The GluN3A subunit exerts a neuroprotective effect in brain ischemia and the hypoxia process.
ASN Neuro null
Diabetes/metabolism research and reviews, 20(2), 137-143 (2004-03-24)
To develop a sensitive, specific screening strategy for predicting genetic risk for type 1 diabetes mellitus (T1DM) in the low-incidence continental Italian population, and to define with this tool, a cohort of high-to-moderate risk infants for an immunological follow-up study
The Lancet. Oncology, 15(8), 886-893 (2014-06-24)
The prognosis for locally advanced gastric cancer is poor despite advances in adjuvant chemotherapy. We did the Stomach cancer Adjuvant Multi-Institutional group Trial (SAMIT) to assess the superiority of sequential treatment (paclitaxel then tegafur and uracil [UFT] or paclitaxel then
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