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Showing 1-28 of 28 results for "08171" within Papers
T C Ma et al.
Arzneimittel-Forschung, 43(10), 1049-1052 (1993-10-01)
The effects of 20(S)-ginsenoside-Rg2 (GRg2, CAS 52286-74-5) and cyproheptadine (CYP, CAS 129-03-3) on acquisition, retention and retrieval were examined in male Wistar rats using a two-way active avoidance method. Learning and memory were estimated by the avoidance rate (%) and/or
Xiuwei Yang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(10), 1281-1284 (2009-08-14)
To determine the ginsenoside Rg2 and study its excretion in bile, feces and urine of rat. Reversed phase high-performance liquid chromatographic (RP-HPLC) method with an ultra-violet detector (UVD) was performed at a detection wavelength of 203 nm and with a
Xiujuan Xin et al.
American journal of therapeutics, 13(3), 205-210 (2006-06-15)
From the cultured cells of Panax notoginseng, a kind of ginseng saponin-ginsenoside Rg2, was separated and purified, and its structure was elucidated as 6-O-[alpha-L-rhamnose (l-->2)-beta-D-glucopyranosyl]3beta, 12beta, 20(S)-trihydroxydammar-24-ene [20(S)-ginsenoside Rg2]. Moreover, its bioactivity stimulates human umbilical cord vein endothelial cell proliferation;
K Kudo et al.
European journal of pharmacology, 341(2-3), 139-144 (1998-05-23)
To investigate the relationship between the inhibitory effects of ginseng saponins (ginsenosides) on acetylcholine-evoked secretion of catecholamines and the structures of ginsenosides, we examined the effects of ginsenoside-Rg3 and -Rh2, which are panaxadiol saponins, 20(R)- and 20(S)-ginsenoside-Rg2, which are epimers
Se Jin Jeong et al.
International journal of toxicology, 26(2), 151-158 (2007-04-25)
Ginseng has been used worldwidely as a traditional medicine of Asian countries for treatment of various diseases including cancer. The purpose of this study was to determine the effect of ginseng saponin mRg2, a mixture of ginsenosides containing 60% Rg2
Young-Suk Cho et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 17(2), 133-137 (2013-04-30)
Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has been used for prevention
Sung-Ryong Ko et al.
Planta medica, 69(3), 285-286 (2003-04-05)
During investigations on the hydrolysis of a protopanaxatriol-type saponin mixture by various glycoside hydrolases, it was found that two minor saponins, ginsenosides Rg 2 and Rh 1, were formed in high yields by crude beta-galactosidase from Aspergillus oryzae and crude
Francisco Sala et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 1052-1059 (2002-05-23)
Ginseng saponins, major active components of ginseng root used by folk medicine in the treatment of various diseases, produce multiple pharmacological responses having many effects on the central and peripheral nervous system. Specifically, ginsenoside Rg(2) has been shown to block
Studies on the saponins of ginseng. II. Structures of ginsenoside-Re,-Rf and-Rg2.
Sanada S, et al.
Chemical & Pharmaceutical Bulletin, 22(10), 2407-2412 (1974)
Sung-Ryong Ko et al.
Chemical & pharmaceutical bulletin, 51(4), 404-408 (2003-04-04)
During investigation of the hydrolysis of a protopanaxatriol-type saponin mixture by various glycoside hydrolases, crude preparations of beta-galactosidase from Aspergillus oryzae and lactase from Penicillium sp. were found to produce two minor saponins, ginsenoside Rg(2) [6-O-(alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl)-20(S)-protopanaxatriol] and ginsenoside Rh(1) (6-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol)
X Zhou et al.
Se pu = Chinese journal of chromatography, 18(6), 546-549 (2003-01-25)
A computer-assisted method is presented for optimization of mobile phase selection for separation of the mixture of ginsenosides in two-dimensional TLC. This method bases on the correlation between the proportions of mobile phases and the retention values Rf of ginsenosides
S R Yoon et al.
Chemical & pharmaceutical bulletin, 46(7), 1144-1147 (1998-08-06)
We have developed an enzyme immunoassay (EIA) to quantify trace amounts of ginsenoside Rf (Rf), one of the glycosides of protopanaxatriol from Panax ginseng. A carrier protein of bovine serum albumin (BSA) was coupled to the carbohydrate component of Rf
S R Ko et al.
Bioscience, biotechnology, and biochemistry, 64(12), 2739-2743 (2001-02-24)
It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg1, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh1 [6-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the
Jun-Ling Cao et al.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 28(1), 54-57 (2008-04-19)
To establish a new method for screening active ingredients of Chinese herbs by determining different bio-thermodynamic effects of 3 genosides on splenic lymphocyte of mice. Using a thermal bioactivity monitoring system, the maximum heat output (mHO), average metabolic heat (MH)
Jun-Ho Lee et al.
Archives of pharmacal research, 26(10), 868-873 (2003-11-12)
Ginsenosides, major active ingredients of Panax ginseng, that exhibit various pharmacological and physiological actions are transformed into compound K (CK) or M4 by intestinal microorganisms. CK is a metabolite derived from protopanaxadiol (PD) ginsenosides, whereas M4 is a metabolite derived
Hai-Dan Yuan et al.
Chemico-biological interactions, 195(1), 35-42 (2011-11-09)
Panax ginseng is known to have anti-diabetic activity, but the active ingredients have not been fully explored yet. Here, we test whether ginsenoside Rg2 has an inhibitory effect on hepatic glucose production and determine its mechanism of action. Rg2 significantly
Wang Shuangyan et al.
Artificial cells, blood substitutes, and immobilization biotechnology, 40(1-2), 142-145 (2011-11-16)
We investigated the neuroprotective effects of Rg(2) in anoxic cultured hippocampal neurons of newborn rats. The cells were divided into a control group, nimodipine group (5 μmol/L), Rg(2) (0.025 mmol/L), and Rg(2) (0.05 mmol/L) group. The apoptosis rate of hippocampal
Fang-Jin Gui et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 850(1-2), 1-6 (2006-11-23)
20 (R,S)-Ginsenoside-Rg2, an anti-shock agent, is prescribed as a racemate. To analyze simultaneously the enantiomers of 20 (R)-ginsenoside-Rg2 and 20 (S)-ginsenoside-Rg2 in plasma, a simple and reproducible high-performance liquid chromatographic (HPLC) method has been developed. The enantiomeric separation and determination
S Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 15(1), 39-40 (1990-01-01)
20(S)-Ginsenoside-Rg2 and its 20(R) epimer were successfully separated using reversed-phase low pressure column (Rp-18) chromatography. The method has proved very convenient and rapid.
Li Jun Li et al.
Food chemistry, 245, 1070-1078 (2017-12-31)
The glycoside hydrolase, α-l-rhamnosidase, could remove the bitter taste of naringin from citrus juices. However, most α-l-rhamnosidases are easily deactivated at high temperatures, limiting the practice in debittering citrus juices. The V529A mutant of the α-l-rhamnosidase r-Rha1 from Aspergillus niger
Guizhi Zhang et al.
Journal of ethnopharmacology, 115(3), 441-448 (2007-12-18)
Ginsenosides, the major active ingredients of Panax ginseng, produce a variety of pharmacological or physiological responses with effects on the central and peripheral nervous systems. In this report, we investigated the effects of ginsenoside Rg2 on cerebral ischemia-reperfusion induced impairment
Seok Choi et al.
Molecules and cells, 15(1), 108-113 (2003-03-29)
Treatment with ginsenosides, major active ingredients of Panax ginseng, produces a variety of pharmacological or physiological responses with effects on the central and peripheral nervous systems. Recent reports showed that ginsenoside Rg2 inhibits nicotinic acetylcholine receptor-mediated Na+ influx and channel
J Lu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 26(8), 556-558 (2003-06-05)
To investigate the protective effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidant properties. Twenty mongrel dogs were randomly divided into Rg2 group, Shen Mai group and control group. The hemorrhagic shock model was built in all dogs
Se Eun Ha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 382(1), 89-101 (2010-05-29)
Our previous study demonstrated the increase in the repair of UVB damage by mRg2, a mixture of ginsenosides containing 60% Rg2 in NIH3T3 cells. In the present study, the effects of purified Rg2 on the repair and apoptosis in ultraviolet
Guangtong Chen et al.
Journal of natural products, 70(7), 1203-1206 (2007-07-17)
Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg1 (1), notoginsenoside-R1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted into five metabolites, ginsenoside-Rh4 (4), 3beta,2beta,25-trihydroxydammar-(E)-20(22)-ene-6-O-beta-D-glucopyranoside (5), 20(S)-ginsenoside-Rh1 (6), 20(R)-ginsenoside-Rh1 (7), and a mixture of 25-hydroxy-20(S)-ginsenoside-Rh1 and
Jian-ming Tian et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 28(12), 1191-1192 (2004-12-25)
To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia. The models of myocardial ischemia were built in rats with isoproterenol, sodium nitrite,pituitrin. Ginsenoside Rg2 (iv 2.5, 5.0, 10.0 mg x kg(-1)) were intravenously administered. Ginsenoside Rg2 could
Na Li et al.
Journal of ethnopharmacology, 111(3), 458-463 (2007-01-30)
We investigated the effect of ginsenoside Rg2 on neurotoxic activities induced by glutamate in PC12 cells. The cells were incubated with glutamate (1 mmol/L), glutamate and ginsenoside Rg2 (0.05, 0.1, 0.2 mmol/L) or nimodipine (5 micromol/L) for 24 h. The
E Tachikawa et al.
Biochemical pharmacology, 62(7), 943-951 (2001-09-07)
Since ginsenoside-Rg(3), one of the panaxadiol saponins isolated from the ginseng root, significantly inhibited the secretion of catecholamines from bovine adrenal chromaffin cells stimulated by acetylcholine (ACh), the properties of ginsenoside-Rg(3) inhibition were investigated. Although ginsenoside-Rg(3) inhibited the secretion evoked
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