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Showing 1-12 of 12 results for "1.24568" within Papers

Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein.

Jan P M Langeveld et al.

Veterinary research, 52(1), 59-59 (2021-04-18)

The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrPSc, aberrant depositions of the host's cellular prion protein (PrPC). Successive heat treatment in the presence of detergent and proteolysis by a keratinase from Bacillus

Sub-Lethal 5-Fluorouracil Dose Challenges Planarian Stem Cells Promoting Transcriptional Profile Changes in the Pluripotent Sigma-Class Neoblasts.

Gaetana Gambino et al.

Biomolecules, 11(7) (2021-07-03)

Under physiological conditions, the complex planarian neoblast system is a composite of hierarchically organized stem cell sub-populations with sigma-class neoblasts, including clonogenic neoblasts, endowed with larger self-renewal and differentiation capabilities, thus generating all the other sub-populations and dominating the regenerative

The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

L Bruno et al.

Immunity, 5(4), 343-352 (1996-10-01)

In peripheral lymphoid tissues of TCR transgenic mice that express the nominal antigen (HY peptide plus H-2Db MHC) recognized by the transgenic TCR, there exist unusual CD4-CD8- and CD4-CD8low cells bearing the transgenic TCR. Here we show that, unlike TCR

Innate Lymphoid Cells in the Induction of Obesity.

Takaharu Sasaki et al.

Cell reports, 28(1), 202-217 (2019-07-04)

Complex interactions between immune cells are an important component in the induction of obesity. Here, we show that Il2rg-/-Rag2-/- mice lacking all lymphocytes are resistant to diet-induced obesity. Transplantation of bone marrow cells from Rag2-/- mice, which lack only acquired

Detection of mRNA by Whole Mount in situ Hybridization and DNA Extraction for Genotyping of Zebrafish Embryos.

Rachna Narayanan et al.

Bio-protocol, 9(6), e3193-e3193 (2019-03-20)

In situ hybridization is used to visualize the spatial distribution of gene transcripts in tissues and in embryos, providing important information about disease and development. Current methods involve the use of complementary riboprobes incorporating non-radioactive labels that can be detected

Mechanism of circadian regulation of the NRF2/ARE pathway in renal ischemia-reperfusion.

Qian Sun et al.

Experimental and therapeutic medicine, 21(3), 190-190 (2021-01-26)

The nuclear erythroid 2-related factor 2 (NRF2)/antioxidant response element (ARE) pathway has been shown to provide strong protection against oxidative stress injury induced by renal ischemia-reperfusion (IR). However, the endogenous regulatory mechanism of the NRF2/ARE pathway in renal IR injury

Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential.

Mihnea R Mangalea et al.

Cell host & microbe, 29(5), 726-739 (2021-05-07)

Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA

Intergenerational effect of short-term spaceflight in mice.

Keisuke Yoshida et al.

iScience, 24(7), 102773-102773 (2021-07-20)

As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of

A generic protocol for the affinity-purification of native macromolecular complexes from poxvirus-infected cells.

Julia Bartuli et al.

STAR protocols, 3(1), 101116-101116 (2022-02-05)

The functional and structural characterization of macromolecular complexes requires protocols for their native isolation. Here, we describe a protocol for this task based on the recombinant poxvirus Vaccinia expressing tagged proteins of interest in infected cells. Tagged proteins and their

Cutinase-like enzyme from the yeast Cryptococcus sp. strain S-2 hydrolyzes polylactic acid and other biodegradable plastics.

Kazuo Masaki et al.

Applied and environmental microbiology, 71(11), 7548-7550 (2005-11-05)

A purified lipase from the yeast Cryptococcus sp. strain S-2 exhibited remote homology to proteins belonging to the cutinase family rather than to lipases. This enzyme could effectively degrade the high-molecular-weight compound polylactic acid, as well as other biodegradable plastics

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.

André R A Marques et al.

Autophagy, 16(5), 811-825 (2019-07-10)

CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads to a strong impairment of the lysosomal-autophagy machinery. In mice

Correlation of conversion of Salmonella enterica serovar enteritidis phage type 1, 4, or 6 to phage type 7 with loss of lipopolysaccharide.

D L Baggesen et al.

Journal of clinical microbiology, 35(1), 330-333 (1997-01-01)

Studies of pairs of Salmonella enterica serovar Enteritidis isolates from different poultry flocks showed that phage type (PT) 7 may be derived from PT 1, 4, and 6. The conversion appeared to be associated with loss of lipopolysaccharide. It is

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