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Showing 1-16 of 16 results for "11093657910" within Papers
Joseph L Bedont et al.
eLife, 10 (2021-06-05)
Sleep is a conserved and essential behavior, but its mechanistic and functional underpinnings remain poorly defined. Through unbiased genetic screening in Drosophila, we discovered a novel short-sleep mutant we named argus. Positional cloning and subsequent complementation, CRISPR/Cas9 knock-out, and RNAi
Shun Sawatsubashi et al.
Scientific reports, 8(1), 593-593 (2018-01-14)
CRISPR/Cas9-based genome editing has dramatically accelerated genome engineering. An important aspect of genome engineering is efficient knock-in technology. For improved knock-in efficiency, the non-homologous end joining (NHEJ) repair pathway has been used over the homology-dependent repair pathway, but there remains
Jiaqiang Wang et al.
Cell, 175(7), 1887-1901 (2018-12-15)
In early mammalian embryos, it remains unclear how the first cell fate bias is initially triggered and amplified toward cell fate segregation. Here, we report that a long noncoding RNA, LincGET, is transiently and asymmetrically expressed in the nucleus of
Ira Male et al.
eNeuro, 7(6) (2020-10-28)
Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in both larval and adult zebrafish and
Guining Zhu et al.
Frontiers in microbiology, 10, 2115-2115 (2019-09-26)
The sugarcane smut fungus Sporisorium scitamineum is bipolar and produces sporidia of two different mating types. During infection, haploid cells of opposite mating types can fuse to form dikaryotic hyphae that can colonize plant tissue. Mating and filamentation are therefore
Diana C Garcia-Ramon et al.
Microbial biotechnology, 11(2), 302-316 (2017-10-14)
Bacillus pumilus strain 15.1 was previously found to cause larval mortality in the Med-fly Ceratitis capitata and was shown to produce crystals in association with the spore. As parasporal crystals are well-known as invertebrate-active toxins in entomopathogenic bacteria such as
Andreas R Gruber et al.
Molecular biology and evolution, 25(9), 1923-1930 (2008-06-21)
The 7SK small nuclear RNA (snRNA) is a key player in the regulation of polymerase (pol) II transcription. The 7SK RNA was long believed to be specific to vertebrates where it is highly conserved. Homologs in basal deuterostomes and a
Bong-Kyeong Oh et al.
PloS one, 14(11), e0225302-e0225302 (2019-11-23)
Telomeric repeat-containing RNAs (TERRAs) are long noncoding RNAs transcribed from subtelomeres toward telomeric repeat tracts, which have been implicated in telomere protection and heterochromatin formation. Genotoxic stress leads to upregulation of TERRAs. However, the mechanism of DNA damage-mediated TERRA induction
Nasser Shakhssalim et al.
Cancer cell international, 13(1), 120-120 (2013-12-07)
Bladder cancer is a relatively common and potentially life-threatening neoplasm that ranks ninth in terms of worldwide cancer incidence. The aim of this study was to determine deletions and sequence variations in the mitochondrial displacement loop (D-loop) region from the
Betim Karahoda et al.
Nucleic acids research, 50(17), 9797-9813 (2022-09-13)
Chromatin complexes control a vast number of epigenetic developmental processes. Filamentous fungi present an important clade of microbes with poor understanding of underlying epigenetic mechanisms. Here, we describe a chromatin binding complex in the fungus Aspergillus nidulans composing of a
Handeng Liu et al.
Journal of invertebrate pathology, 99(2), 235-238 (2008-07-22)
Among Microsporidia, Nosema bombycis has a novel arrangement of LSUrRNA, SSUrRNA, ITS, IGS and 5SrRNA. To determine the distribution of rDNA among the chromosomes, we performed genome-wide screening and Southern blotting with three probes (SSU, ITS and IGS). Southern blotting
Hongshun Li et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The vegetative phase transition is a prerequisite for flowering in angiosperm plants. Mulberry miR156 has been confirmed to be a crucial factor in the vegetative phase transition in Arabidopsis thaliana. The over-expression of miR156 in transgenic Populus × canadensis dramatically
Jiaqiang Wang et al.
EMBO reports, 17(10), 1452-1470 (2016-08-09)
Endogenous retroviruses (ERVs) are transcriptionally active in cleavage stage embryos, yet their functions are unknown. ERV sequences are present in the majority of long intergenic noncoding RNAs (lincRNAs) in mouse and humans, playing key roles in many cellular processes and
Jing Qi et al.
Molecular medicine reports, 12(6), 8268-8274 (2015-10-16)
The aim of the present study was to genetically modify plantlets of the Chinese yali pear to reduce their expression of ripening-associated 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) and therefore increase the shelf-life of the fruit. Primers were designed with selectivity for
Sameera Hassan et al.
Iranian journal of biotechnology, 18(2), e2312-e2312 (2021-02-06)
Drought stress seriously affects the cotton fiber development. Universal stress protein gene isolated from native species Gossypium arboreum has the promising tolerance role against these stresses. This study aimed to clone, characterize, and genetically transform the GUSP1 gene in local
Maxime Lafont et al.
Scientific reports, 7(1), 13143-13143 (2017-10-17)
In the last decade, a paradigm shift has emerged in comparative immunology. Invertebrates can no longer be considered to be devoid of specific recognition and immune memory. However, we still lack a comprehensive view of these phenomena and their molecular
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