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Showing 1-24 of 24 results for "11363514910" within Papers
Karoline E Kokot et al.
Basic research in cardiology, 117(1), 32-32 (2022-06-24)
Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA editing in failing human hearts. Transcriptome sequencing showed that adenosine-to-inosine (A-to-I) RNA editing was responsible for 80% of the editing events
Jean-Félix Dallery et al.
Molecular plant pathology, 20(6), 831-842 (2019-03-30)
The role of histone 3 lysine 4 (H3K4) methylation is poorly understood in plant pathogenic fungi. Here, we analysed the function of CclA, a subunit of the COMPASS complex mediating H3K4 methylation, in the brassica anthracnose pathogen Colletotrichum higginsianum. We
Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.
Legnini I, et al.
Molecular Cell, 66(1), 22-37 (2017)
Joachim Michael Matz et al.
Cell reports, 26(2), 356-363 (2019-01-10)
Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing cell populations, including tumors and malaria parasites. Genome data suggest that Plasmodium has retained its capacity to generate folates de novo. However, the metabolic plasticity of
Guan-Long Wu et al.
PloS one, 11(7), e0158663-e0158663 (2016-07-09)
Five Aphelenchoides besseyi isolates collected from bird's-nest ferns or rice possess different parasitic capacities in bird's-nest fern. Two different glycoside hydrolase (GH) 45 genes were identified in the fern isolates, and only one was found in the rice isolates. A
Claudia Sigl et al.
Applied and environmental microbiology, 77(3), 972-982 (2010-12-15)
In filamentous fungi, secondary metabolism is often linked with developmental processes such as conidiation. In this study we analyzed the link between secondary metabolism and conidiation in the main industrial producer of the β-lactam antibiotic penicillin, the ascomycete Penicillium chrysogenum.
Ivano Legnini et al.
Molecular cell, 66(1), 22-37 (2017-03-28)
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of physiologically relevant processes is still
Xinyan Li et al.
Cell reports, 34(7), 108741-108741 (2021-02-18)
Mossy cells (MCs) are a unique group of excitatory neurons in the hippocampus, a brain region important for emotion, learning, and memory. Due to the lack of a reliable method to isolate MCs from other cell types, how MCs integrate
Jes-Niels Boeckel et al.
Circulation research, 117(10), 884-890 (2015-09-18)
Circular RNAs (circRNAs) are noncoding RNAs generated by back splicing. Back splicing has been considered a rare event, but recent studies suggest that circRNAs are widely expressed. However, the expression, regulation, and function of circRNAs in vascular cells is still
Karl Dichtl et al.
Molecular microbiology, 95(3), 458-471 (2014-11-27)
Echinocandins inhibit β-1,3-glucan synthesis and are one of the few antimycotic drug classes effective against Aspergillus spp. In this study, we characterized the β-1,3-glucan synthase Fks1 of Aspergillus fumigatus, the putative target of echinocandins. Data obtained with a conditional mutant
Fang Zheng et al.
Nature communications, 12(1), 1341-1341 (2021-02-28)
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to
María Rodríguez-López et al.
Cell reports, 30(10), 3240-3249 (2020-03-12)
Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous transcriptional regulation is less understood. Here
Fang Liu et al.
International journal of molecular sciences, 22(22) (2021-11-28)
It is vital to develop high-throughput methods to determine transgene copy numbers initially and zygosity during subsequent breeding. In this study, the target sequence of the previously reported endogenous reference gene hmg was analyzed using 633 maize inbred lines, and
Jonas Protze et al.
Frontiers in microbiology, 2, 68-68 (2011-07-13)
The thermoacidophilic and chemolithotrophic archaeon Acidianus ambivalens is routinely grown with sulfur and CO(2)-enriched air. We had described a membrane-bound, tetrathionate (TT) forming thiosulfate:quinone oxidoreductase. Here we describe the first TT hydrolase (TTH) from Archaea. A. ambivalens cells grown aerobically
Zhijie Lin et al.
Discover. Oncology, 13(1), 32-32 (2022-05-17)
Lung cancer is the malignancy most commonly seen worldwide. Emerging evidences indicated that lncRNAs may serve as a prognosis marker and play important role in NSCLC tumor biology. In this work, we analyzed the prognosis value of RP11-10A14.5 using TCGA
Yufan Li et al.
Nature communications, 12(1), 4470-4470 (2021-07-24)
Gravity is a critical environmental factor regulating directional growth and morphogenesis in plants, and gravitropism is the process by which plants perceive and respond to the gravity vector. The cytoskeleton is proposed to play important roles in gravitropism, but the
Eirini Vamva et al.
Nucleic acids research, 50(1), 430-448 (2021-12-21)
Clinical usage of lentiviral vectors is now established and increasing but remains constrained by vector titer with RNA packaging being a limiting factor. Lentiviral vector RNA is packaged through specific recognition of the packaging signal on the RNA by the
Yang Qiu et al.
Immunity, 46(6), 992-1004 (2017-06-22)
RNA interference (RNAi) functions as a potent antiviral immunity in plants and invertebrates; however, whether RNAi plays antiviral roles in mammals remains unclear. Here, using human enterovirus 71 (HEV71) as a model, we showed HEV71 3A protein as an authentic
Takuya Okamoto et al.
STAR protocols, 2(4), 100780-100780 (2021-09-30)
Patient-derived organoids (PDOs) recapitulate the cellular heterogeneity of the original colorectal tumor tissue. Here, we describe a protocol to generate genetically modified PDOs to investigate cancer stem cells. This protocol uses the CRISPR-Cas9 system to knock-in the IRES-EGFP-P2A-iCaspase9 cassette into
Dongqing Huang et al.
Genetics, 203(1), 353-368 (2016-03-28)
In response to replication stress, a phospho-signaling cascade is activated and required for coordination of DNA repair and replication of damaged templates (intra-S-phase checkpoint) . How phospho-signaling coordinates the DNA replication stress response is largely unknown. We employed state-of-the-art liquid
Yanchang Luo et al.
Plant biotechnology (Tokyo, Japan), 37(1), 69-75 (2020-05-05)
Retrotransposons are mobile genetic elements capable of transposition via reverse transcription of RNA intermediates. Rice cultivar Nipponbare contains two nearly identical genomic copies of Tos17, an endogenous copia-like LTR retrotransposon, on chromosomes 7 (Tos17 Chr.7) and 10 (Tos17 Chr.10), respectively.
DNA Replication Stress Phosphoproteome Profiles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiae.
Huang D, et al.
Genetics, 203(1), 353-368 (2016)
Nannan Zhang et al.
Current protocols in immunology, 126(1), e78-e78 (2019-09-05)
MicroRNAs (miRNAs) are short (19- to 25-nucleotide) noncoding RNA molecules that target mRNAs to repress gene expression and that play important roles in regulating many fundamental biological functions including cell differentiation, development, growth, and metabolism. They are well conserved in
Céline Lacroix et al.
Nature protocols, 6(9), 1412-1428 (2011-09-03)
We describe here a highly efficient procedure for conditional mutagenesis in Plasmodium. The procedure uses the site-specific recombination FLP-FRT system of yeast and targets the pre-erythrocytic stages of the rodent Plasmodium parasite P. berghei, including the sporozoite stage and the
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